Pulmonary rehabilitation for adults on high-flow oxygen

Evaluation of the Effect of Pulmonary Rehabilitation on Patients With High Flow Oxygen Therapy

This test checks whether adding pulmonary rehabilitation helps adults in the ICU who are receiving high-flow humidified oxygen support.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 70 (estimated)
• Ages: 18 Years to 100 Years
• Sex: All
• Sponsor: Chinese PLA General Hospital (Academic / other)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT04441151 on ClinicalTrials.gov

What this trial studies

This randomized interventional study enrolled 70 ICU patients receiving high-flow humidified oxygen and assigned them to pulmonary rehabilitation plus routine care or to routine care alone. The intervention arm received a program of pulmonary rehabilitation while the control arm continued standard medical treatment. Measurements at admission and discharge included bedside diaphragm ultrasound, MRC sum for peripheral muscle strength, a 30‑second sit test, the modified Barthel index, Borg dyspnea score, arterial blood gases, and daily vital sign monitoring; use of noninvasive ventilation, intubation, new complications, and time to first out-of-bed were also recorded. The follow-up period and primary endpoint assessment extended to 28 days.

Who should consider this trial

Good fit: Adults (≥18 years) in the ICU treated with high-flow humidified oxygen who are hemodynamically and neurologically stable, with adequate oxygen saturation and respiratory rate, and without contraindications such as active bleeding or recent fractures.

Not a fit: Patients who are hemodynamically unstable, pregnant, actively bleeding, with recent cardio‑cerebrovascular events, unresolved spinal or limb fractures, or uncontrolled seizures are unlikely to be eligible or to benefit.

Why it matters

Potential benefit: If successful, adding pulmonary rehabilitation could speed respiratory and functional recovery, reduce the need for noninvasive ventilation or intubation, and lower complication rates.

How similar studies have performed: Prior ICU mobilization and pulmonary rehabilitation programs have shown improved muscle strength, functional status, and reduced ventilator days, although direct evidence specifically in patients on high-flow oxygen is limited.

Eligibility criteria

Inclusion Criteria:

* The age is ≥ 18 years old;
* the hemodynamics is stable;
* 50 \< heart rate \< 120 beats / min ;
* 90 \< systolic blood pressure \< 200mmHg ;
* 55 \< mean arterial pressure \< 120mmHg;
* do not increase the dose of pressor drugs for at least 2 hours;
* intracranial pressure is stable and there are no seizures within 24 hours;
* the respiratory state is stable;
* the patient's finger pulse oxygen saturation ≥ 88%;
* 10 \< respiratory frequency \< 35 beats / min.

Exclusion Criteria:

* Pregnancy;
* acute cardio-cerebrovascular events;
* spinal or limb fractures;
* active bleeding.

Where this trial is running

Beijing, Beijing Municipality

• Chinese PLAGH Hospital — Beijing, Beijing Municipality, China (Recruiting)

Study contacts

• Principal investigator: wang, doctor — The First Medical Center of PLA General Hospital
• Study coordinator: kai fei Wang

Conditions Pulmonary Disease