New treatments for lung disease caused by Mycobacterium abscessus
Official title: Novel strategies for treatment of Mycobacterium abscessus pulmonary disease
Funded at Medical University of South Carolina · NIH-11011626 · Data updated 2026-11-12
This study is testing a new antibiotic called omadacycline to see if it can help older adults and people with lung problems who have a tough-to-treat infection caused by Mycobacterium abscessus, and we want to find out how well it works and if it's safe.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | June 2, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $240,878 |
| NIH project number | 1R34AI186857-01 |
| Project ID | NIH-11011626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly women, who have pulmonary disease caused by Mycobacterium abscessus.
✕Less likely to help
Patients who do not have pulmonary disease or are younger than 21 years old may not benefit from this research.
What this research studies
This research focuses on developing effective treatments for pulmonary disease caused by Mycobacterium abscessus, particularly in older adults and those with existing lung conditions. The study will evaluate the antibiotic omadacycline, which has shown promise against this resistant bacterium, in a randomized, blinded, placebo-controlled trial. Researchers aim to gather comprehensive data on the drug's efficacy and safety, as well as establish a framework for future clinical trials in this area. Patient-reported outcomes, microbiologic data, and imaging results will be integral to the study's methodology.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients suffering from a challenging lung disease.
How similar studies have gone: While there have been observational studies suggesting the potential of omadacycline, rigorous clinical trials for this specific treatment approach are currently lacking.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Dorman, Susan E — Medical University of South Carolina
- Study coordinator: Dorman, Susan E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.