Shorter all-oral treatments for Mycobacterium abscessus lung infections
Shorter and more effective oral regimens for M. abscessus pulmonary disease
Developing shorter, all-oral drug combinations to better cure Mycobacterium abscessus lung infections and reduce treatment time and side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-11261782 on NIH RePORTER |
What this research studies
Researchers will build treatment combinations made entirely of oral drugs, prioritizing fast-killing antibiotics to quickly lower bacterial levels in the lungs. They will screen commonly used and new antibiotic candidates to make sure they work together without blocking the killers. Promising regimens will be tested in lab experiments and a mouse model of M. abscessus lung infection to pick the best options. The goal is to move the best oral combinations toward clinical testing so patients can avoid long, injectable-heavy therapies.
Who could benefit from this research
Good fit: People with confirmed Mycobacterium abscessus pulmonary disease, especially those who have failed or cannot tolerate current long, partly injectable regimens, are the likely candidates for future trials.
Not a fit: Patients with non–M. abscessus infections (for example other NTM species), or those needing immediate intensive inpatient care, may not benefit from these oral regimens.
Why it matters
Potential benefit: If successful, this work could shorten treatment courses, avoid intravenous antibiotics, and improve cure rates with fewer side effects.
How similar studies have performed: Existing treatments for M. abscessus have had limited success and cures are uncommon, so creating sterilizing all-oral regimens is a relatively new and much-needed approach that builds on antibiotic-combination experience.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Dick, Thomas — Hackensack University Medical Center
- Study coordinator: Dick, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.