New treatment options for Mycobacterium avium lung disease
Official title: Short course combination regimens for treatment of Mycobacterium avium pulmonary disease: a translational bench-to-bedside approach
Funded at University of Texas Hlth Ctr at Tyler · NIH-10997350 · Data updated 2026-11-12
This study is looking for better and quicker ways to treat lung infections caused by Mycobacterium avium complex (MAC) by testing different combinations of antibiotics, so patients can get healthier faster with less time on medication.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Ctr at Tyler NIH-funded |
| Lab location | 1 site (Tyler, United States) |
| Project start | December 8, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $549,164 |
| NIH project number | 5R01AI179827-02 |
| Project ID | NIH-10997350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary Mycobacterium avium complex infections who are seeking alternative treatment options.
✕Less likely to help
Patients with other types of pulmonary infections or those who do not have Mycobacterium avium complex may not benefit from this research.
What this research studies
This research investigates more effective and shorter treatment regimens for pulmonary disease caused by Mycobacterium avium complex (MAC). It aims to identify the best combinations of existing and new antibiotics through a systematic screening process. By understanding how these drugs work together, the research seeks to improve treatment outcomes and reduce the duration of therapy needed for patients. The approach is designed to fill existing gaps in knowledge regarding drug interactions and optimal dosing.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that shorten the duration of therapy for patients with MAC pulmonary disease.
How similar studies have gone: Previous research has shown promise in developing new antibiotic combinations for treating similar infections, indicating potential for success in this approach.
Where this research is happening
-
University of Texas Hlth Ctr at Tyler
Tyler, United States Active
Researchers
- Principal investigator: Kant, Shashi — University of Texas Hlth Ctr at Tyler
- Study coordinator: Kant, Shashi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.