Symptoms and quality of life for people with non-tuberculous mycobacterial lung disease
Official title: Patient reported outcomes in patients with nontuberculous mycobacterial pulmonary disease
Funded at Oregon Health & Science University · NIH-11166697 · Data updated 2026-11-12
This project looks at how cough, fatigue, and daily life are affected in adults with non-tuberculous mycobacterial lung disease and whether patient reports line up with lab tests and cough recordings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $682,008 |
| NIH project number | 5R01HL169759-03 |
| Project ID | NIH-11166697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with non-tuberculous mycobacterial pulmonary disease (such as MAC or M. abscessus), often with bronchiectasis or COPD, who can complete surveys and attend clinic visits are the ideal candidates.
✕Less likely to help
Children, people without NTM lung disease, or those unable to complete questionnaires or provide cough recordings or sputum samples are unlikely to benefit directly from participation.
What this research studies
You would be asked to complete questionnaires about symptoms, daily functioning, and treatment side effects over time. Some participants will provide sputum samples when possible and wear devices or record coughs so researchers can measure cough frequency objectively. The team will compare what patients report with culture results and cough data during and after treatment and follow people for several years. The goal is to understand which patient-reported changes matter most for deciding treatment success and monitoring relapse.
Why it matters
Potential benefit: If successful, this work could help doctors use patient-reported symptoms and objective cough measures to guide treatment decisions and define meaningful treatment outcomes.
How similar studies have gone: Using patient-reported outcomes and cough monitoring has shown value in other lung diseases, but applying these measures specifically to NTM pulmonary disease is relatively new and less tested.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Henkle, Emily M. — Oregon Health & Science University
- Study coordinator: Henkle, Emily M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.