Predicting risk of chronic obstructive pulmonary disease using genetic information
Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations
['FUNDING_CAREER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11059182
This study is looking at how your genes and environment can affect your chances of getting chronic obstructive pulmonary disease (COPD), so we can find out who might be at higher risk and help them get care sooner.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11059182 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic and environmental factors contribute to the risk of developing chronic obstructive pulmonary disease (COPD). By analyzing genetic data from diverse populations, including European and African ancestries, the study aims to create a more accurate risk prediction model. The approach involves developing polygenic risk scores and transcriptional risk scores to identify individuals at high risk for COPD before significant lung damage occurs. This could lead to earlier interventions and better management of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from European and African ancestry populations who may be at risk for chronic obstructive pulmonary disease.
Not a fit: Patients who do not belong to the studied ancestry groups or those who already have advanced COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier identification and intervention for individuals at high risk of developing COPD, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using genetic data for risk prediction in other diseases, suggesting that this approach could be effective for COPD as well.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOLL, MATTHEW R — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: MOLL, MATTHEW R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.