Predicting risk of chronic obstructive pulmonary disease using genetic information
Official title: Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations
Funded at Brigham and Women's Hospital · NIH-11059182 · Data updated 2026-11-12
This study is looking at how your genes and environment can affect your chances of getting chronic obstructive pulmonary disease (COPD), so we can find out who might be at higher risk and help them get care sooner.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $168,480 |
| NIH project number | 5K08HL159318-04 |
| Project ID | NIH-11059182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from European and African ancestry populations who may be at risk for chronic obstructive pulmonary disease.
✕Less likely to help
Patients who do not belong to the studied ancestry groups or those who already have advanced COPD may not benefit from this research.
What this research studies
This research investigates how genetic and environmental factors contribute to the risk of developing chronic obstructive pulmonary disease (COPD). By analyzing genetic data from diverse populations, including European and African ancestries, the study aims to create a more accurate risk prediction model. The approach involves developing polygenic risk scores and transcriptional risk scores to identify individuals at high risk for COPD before significant lung damage occurs. This could lead to earlier interventions and better management of the disease.
Why it matters
Potential benefit: If successful, this research could enable earlier identification and intervention for individuals at high risk of developing COPD, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using genetic data for risk prediction in other diseases, suggesting that this approach could be effective for COPD as well.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Moll, Matthew R — Brigham and Women's Hospital
- Study coordinator: Moll, Matthew R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.