Condition

Primary Aldosteronism clinical trials and research

• 35Clinical trials
• 7NIH research projects
• 2New in 30 days
• 13Countries

Newest Primary Aldosteronism clinical trials

All recruiting trials (35)

• Kidney stiffness measured by ultrasound in hypertension and healthy volunteers

  This study tests whether kidney stiffness measured by a non-invasive ultrasound method differs between people with high blood pressure and healthy individuals.

  Recruiting Azienda Ospedaliera di Padova · Padova, PD · NCT07914075

• Inclisiran vs. Statin for Primary Aldosteronism

  This trial tests whether inclisiran plus amlodipine works differently from a statin-based approach in people with primary aldosteronism and high blood pressure.

  Recruiting Third Military Medical University · Chongqing, Chongqing Municipality · NCT07884955

• Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its Comorbidities

  This study tests how comorbid conditions like sleep apnea and primary aldosteronism relate to left-atrial fibrosis and AF recurrence in patients undergoing ablation.

  Recruiting University Hospital Augsburg · Augsburg, Bavaria · NCT07857044

• Metomidate PET-CT vs Usual Care for Primary Aldosteronism

  This study tests whether [11C] metomidate PET-CT can help orient treatment for people with primary aldosteronism compared with the usual adrenal venous sampling approach.

  Recruiting Chinese University of Hong Kong · Shatin · NCT07814105

• Captopril Test with LC-MS/MS for Aldosterone and Renin in Primary Aldosteronism

  This study tests whether measuring aldosterone with LC-MS/MS during a captopril test can better diagnose primary aldosteronism.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07691801

• Finerenone vs. Spironolactone for Primary Aldosteronism

  This trial tests whether finerenone works as well as spironolactone to lower blood pressure and improve related health measures in adults with primary aldosteronism.

  Recruiting Bangladesh Medical University · Dhaka · NCT07688928

• Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism

  In people with primary aldosteronism, this study tests whether aiming for a systolic BP under 120 mmHg is better than under 140 mmHg for lowering cardiovascular risk.

  Recruiting Chongqing Medical University · Chongqing · NCT07673445

• Precise urinary aldosterone threshold for diagnosing primary aldosteronism using LC-MS/MS during an oral sodium loading test

  This study tests whether measuring urinary aldosterone with LC-MS/MS during the oral sodium loading test can more accurately diagnose primary aldosteronism.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07635134

• Cutoff revision effects and NNT in primary aldosteronism

  This study tests whether using a revised ARR cutoff (>20) helps detect primary aldosteronism in adults with hypertension and intermediate PA probability, and estimates how many people need testing to find one PA case.

  Recruiting Seoul National University Hospital · Seoul, Korea, Republic of · NCT07621458

• Long-term outcomes after treatment for primary aldosteronism

  This project will follow adults with primary aldosteronism for five years to see how different disease subtypes and treatments affect blood pressure, hormone levels, and heart and kidney health.

  Recruiting at 2 sites Xinjiang Medical University · Chengdu, Sichuan and 1 other locations · NCT07378176

• Primary aldosteronism and thinking/memory problems

  This study will see if people aged 40 and older with primary aldosteronism develop memory and thinking problems over 1 to 5 years and which factors influence those changes.

  Recruiting at 2 sites Xinjiang Medical University · Chengdu, Sichuan and 1 other locations · NCT07304674

• Comparing sequential combined and single adrenal venous sampling approaches for primary aldosteronism

  This study will see if three adrenal venous sampling approaches—sequential combined (non‑ACTH then ACTH), non‑ACTH alone, and ACTH‑stimulated alone—lead to better 6‑month treatment outcomes for adults aged 18–70 with primary aldosteronism.

  Recruiting Chongqing Medical University · Chongqing · NCT07298954

• Spironolactone with antihypertensives for unilateral primary aldosteronism

  This project will try different doses of spironolactone together with usual blood-pressure medicines in adults with lateralized primary aldosteronism who decline surgery to see if it relieves renin suppression and lowers long-term cardiovascular risks.

  Recruiting Third Military Medical University · Chongqing, Chongqing Municipality · NCT07137364

• Multi-omics analysis of primary aldosteronism

  This study will test whether multi-omics profiling of people with primary aldosteronism, people with primary hypertension, and healthy volunteers can find biological markers that improve diagnosis and subtyping.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07111351

• Using Gallium-68 Pentixafor PET-CT to improve surgery outcomes in primary aldosteronism

  This trial will test whether adding gallium-68 pentixafor PET/CT to standard adrenal venous sampling helps people with primary aldosteronism have better results from adrenal surgery.

  Recruiting at 2 sites Seoul National University Hospital · Seoul, Gangnam-gu and 1 other locations · NCT07027254

• Evaluating adrenal insufficiency after surgery in patients with primary aldosteronism

  This study is testing how often people with primary aldosteronism develop adrenal insufficiency after having surgery to remove their adrenal glands.

  Recruiting Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06955286

• Screening for Primary Aldosteronism using Steroids

  This study is testing a new steroid-based method to see if it can better identify Primary Aldosteronism in people with high blood pressure who are taking their usual medications.

  Recruiting Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06941116

• Comparing two methods for diagnosing a specific type of adrenal disorder

  This study is testing whether a new imaging method can diagnose adrenal disorders better than a traditional sampling method in patients with adrenal nodules.

  Recruiting Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06833437

• Shortening the Oral Sodium Loading Test for Diagnosing Primary Aldosteronism

  This study is testing if a shorter 2-day sodium loading test can accurately diagnose primary aldosteronism, compared to the traditional 3-day method, for people with this condition.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06750172

• Improving screening for primary aldosteronism in patients with hypertension

  This study is testing if giving a small dose of dexamethasone can help doctors better identify primary aldosteronism in patients with high blood pressure who are already on medication.

  Recruiting Medical University of Gdansk · Gdansk, Pomeranian Voivodeship · NCT06740838

• Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate

  This study is trying to see if a special imaging technique can help doctors better understand different types of primary aldosteronism in patients.

  Recruiting Phase 1/2 University Medical Center Groningen · Groningen, Provincie Groningen · NCT06616142

• Quantifying sodium levels in muscles of patients with primary aldosteronism

  This study is testing a new way to measure sodium levels in the muscles of people with primary aldosteronism to see if it helps improve understanding and treatment of the condition.

  Recruiting at 2 sites Duke-NUS Graduate Medical School · Singapore and 3 other locations · NCT06569589

• Combining statins with amlodipine to treat primary aldosteronism

  This study is testing if combining statins with amlodipine can help people with primary aldosteronism manage their condition better.

  Recruiting Phase 4 Third Military Medical University · Chongqing, Chongqing Municipality · NCT06523465

• Evaluating a new treatment for primary aldosteronism using adrenal artery embolization

  This study is testing a new treatment called adrenal artery embolization to see if it can help people with primary aldosteronism who can’t take medication or have surgery.

  Recruiting Xinjiang Medical University · Ürümqi, Xinjiang · NCT06513676

• Comparing two treatments for primary aldosteronism

  This study is testing whether surgery or a less invasive procedure works better and is safer for people with primary aldosteronism to help manage their high blood pressure.

  Recruiting Xinjiang Medical University · Ürümqi, Xinjiang · NCT06513585

• Dynamic hormone profiling for diagnosing primary aldosteronism

  This study is testing a new way to measure hormone levels in people who might have primary aldosteronism to see if it can help diagnose the condition more easily and accurately.

  Recruiting Haukeland University Hospital · Bergen · NCT06495983

• Comparing recovery after adrenal surgery with and without drainage tubes

  This study is testing whether having surgery for adrenal problems without drainage tubes helps patients recover faster and feel less pain compared to traditional surgery with tubes.

  Recruiting Zhongnan Hospital · Wuhan, Hubei · NCT06250699

• Comparing catecholamine levels in blood during adrenal artery embolization for hypertension

  This study is trying to see how blood pressure changes during a specific treatment for high blood pressure in people with primary aldosteronism and how it relates to certain hormones in the blood.

  Recruiting First Affiliated Hospital of Chengdu Medical College · Chengdu, Sichuan · NCT06228677

• Using renin levels to guide treatment with mineralocorticoid receptor antagonists for Primary Aldosteronism

  This study is testing if measuring renin levels can help doctors adjust the treatment for adults with Primary Aldosteronism who are taking a specific medication to improve their results and reduce side effects.

  Recruiting Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Montreal, Quebec · NCT06108427

• Diagnosing Variable Primary Aldosteronism

  This study is testing if measuring aldosterone levels in urine over 24 hours can help doctors better diagnose people who might have Primary Aldosteronism.

  Recruiting Queen Mary University of London · London · NCT05765786

• Assessing the impact of adrenal artery embolization on blood vessel function in patients with primary aldosteronism

  This study is testing if a procedure called adrenal artery embolization can improve blood vessel function in people with primary aldosteronism compared to taking a medication called spironolactone.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang · NCT05561361

• Evaluating the impact of adrenal artery embolization on heart changes in patients with primary aldosteronism

  This study is testing whether a procedure called adrenal artery embolization can improve heart changes in people with primary aldosteronism compared to taking a medication called spironolactone.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang · NCT05501080

• Endoscopic ultrasound-guided radiofrequency ablation for adrenal tumors in primary aldosteronism

  This study is testing a new non-surgical treatment using ultrasound to see if it can help people with primary aldosteronism and adrenal tumors feel better compared to traditional surgery.

  Recruiting Haukeland University Hospital · Bergen · NCT05368090

• Impact of Aldosterone Blockade on Heart Function in Primary Aldosteronism

  This study is testing if a medication that blocks a hormone called aldosterone can improve heart function in people with primary aldosteronism, which causes high blood pressure.

  Recruiting Phase 4 Brigham and Women's Hospital · Boston, Massachusetts · NCT05030545

• Research on primary aldosteronism and its effects on hypertension

  This study is trying to understand how primary aldosteronism affects high blood pressure over time by looking at a large group of patients and collecting samples to find better ways to manage the condition.

  Recruiting Chongqing Medical University · Chongqing, Chongqing Municipality · NCT03224312

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Unrecognized Primary Aldosteronism and Kidney Disease in Diabetes

  A study at Brigham and Women’s Hospital will explore whether unrecognized primary aldosteronism contributes to kidney disease and heart risk in people with diabetes.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11349753

• Understanding why primary aldosteronism screening is missing or delayed

  A Mayo Clinic-led study aims to understand why many people at risk for primary aldosteronism are not being screened early enough and what can be done to fix it.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11291330

• Understanding heart function and structure in patients with primary aldosteronism

  This study is looking at how primary aldosteronism impacts heart health in people with heart failure that still pumps well, and it will explore how a medication called spironolactone might help improve their heart function and structure.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11200687

• Investigating how unrecognized primary aldosteronism contributes to kidney disease in diabetes

  This study is looking at how a condition called primary aldosteronism might affect kidney health in people with diabetes, and it aims to find those who may not know they have it so they can get the right care to protect their kidneys.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11190882

• Investigating the reasons for low and delayed screening of primary Aldosteronism

  This study is looking into why not enough people at risk for primary aldosteronism get tested for it, even though it can cause serious health problems, and it aims to find ways to make screening easier and more accessible for everyone.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11048613

• Investigating the causes and effects of primary aldosteronism subtypes

  This study is looking at primary aldosteronism, a condition that causes high blood pressure, to find better ways to diagnose it using blood tests and tissue samples, so patients can get the right treatment without needing invasive procedures.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11031933

• Investigating heart function and blood flow in patients with primary aldosteronism.

  This study is looking at how a condition called primary aldosteronism impacts heart health in people with heart failure and how a specific type of medication might help improve their heart function by reducing inflammation, so we can find out who might benefit the most from this treatment.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11013901

Related topics

Quick answers

How many Primary Aldosteronism clinical trials are recruiting right now?

35, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (21 trials), Norway (2 trials), South Korea (2 trials), Singapore (1 trial), United States (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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