Investigating how unrecognized primary aldosteronism contributes to kidney disease in diabetes
Official title: Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes
Funded at Brigham and Women's Hospital · NIH-11190882 · Data updated 2026-11-12
This study is looking at how a condition called primary aldosteronism might affect kidney health in people with diabetes, and it aims to find those who may not know they have it so they can get the right care to protect their kidneys.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2018 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $751,623 |
| NIH project number | 5R01DK115392-07 |
| Project ID | NIH-11190882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with diabetes who may also be at risk for chronic kidney disease and have not been previously diagnosed with primary aldosteronism.
✕Less likely to help
Patients without diabetes or those who do not have chronic kidney disease are unlikely to benefit from this research.
What this research studies
This research focuses on understanding the role of primary aldosteronism (PA) in the development and progression of chronic kidney disease (CKD) among individuals with diabetes. It aims to identify patients who may have undiagnosed PA, which can lead to excessive aldosterone production and subsequent kidney damage. By exploring the mechanisms of PA and its effects on kidney health, the study seeks to improve early detection and treatment strategies for at-risk patients. The research employs a combination of clinical assessments and biomarker analysis to evaluate the prevalence and impact of PA in diabetic populations.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and management strategies for chronic kidney disease in diabetic patients, ultimately improving their health outcomes.
How similar studies have gone: Previous research has indicated that primary aldosteronism is a significant but often unrecognized contributor to kidney disease, suggesting that this approach has potential based on emerging evidence.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Vaidya, Anand — Brigham and Women's Hospital
- Study coordinator: Vaidya, Anand
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.