Unrecognized Primary Aldosteronism and Kidney Disease in Diabetes
Official title: Unrecognized Primary Aldosteronism as a Pathogenic Mechanism for Chronic Kidney Disease in Diabetes
Funded at Brigham and Women's Hospital · NIH-11349753 · Data updated 2026-11-12
A study at Brigham and Women’s Hospital will explore whether unrecognized primary aldosteronism contributes to kidney disease and heart risk in people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2018 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $748,508 |
| NIH project number | 5R01DK115392-08 |
| Project ID | NIH-11349753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with diabetes and chronic kidney disease, especially those with high cardiovascular risk or albuminuria.
✕Less likely to help
People without diabetes-related CKD or without evidence of PA pathophysiology may not benefit.
What this research studies
If you have diabetes and kidney disease, this research looks at a hormone-related condition called primary aldosteronism that may drive inflammation and scarring in the kidneys and heart. The team will examine how aldosterone signaling affects kidney damage and cardiovascular outcomes, and whether identifying and targeting this pathway could slow disease. The researchers aim to build a better understanding of who is affected and how to improve screening and treatment strategies for these patients. This work could pave the way for earlier detection and personalized therapies to protect kidney and heart health in diabetes.
Why it matters
Potential benefit: If successful, the study could lead to earlier detection of PA-related kidney damage and new treatment approaches to prevent progression and cardiovascular complications in diabetes.
How similar studies have gone: Previous work suggests PA pathophysiology is present in a notable portion of high-risk populations, but broader testing and targeted therapies are still being explored.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Vaidya, Anand — Brigham and Women's Hospital
- Study coordinator: Vaidya, Anand
Related research
Other NIH-funded projects on the same topics.
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Investigating how unrecognized primary aldosteronism contributes to kidney disease in diabetes
This study is looking at how a condition called primary aldosteronism might affect kidney health in people with diabetes, and it aims to find those who may not know they have it so they can get the right care to protect their kidneys.
-
Rapid, multi-drug initiation for people with CKD and type 2 diabetes
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-
Improving bone health in patients with diabetes and chronic kidney disease
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.