Understanding heart function and structure in patients with primary aldosteronism

Who could benefit from this research

What this research studies

This research investigates how primary aldosteronism affects heart function and structure, particularly in patients with heart failure with preserved ejection fraction (HFpEF). It aims to explore the mechanisms by which mineralocorticoid receptor antagonists, like spironolactone, can improve heart health in these patients. The study will involve assessing cardiac perfusion, structure, and function through advanced imaging techniques and clinical evaluations. By understanding these relationships, the research seeks to identify better treatment strategies for those affected by this condition.

Why it matters

Where this research is happening

• Brigham and Women's Hospital
  Boston, United States Active

Researchers

• Principal investigator: Brown, Jenifer Michelle — Brigham and Women's Hospital
• Study coordinator: Brown, Jenifer Michelle

Related research

Other NIH-funded projects on the same topics.

• Unrecognized Primary Aldosteronism and Kidney Disease in Diabetes

  A study at Brigham and Women’s Hospital will explore whether unrecognized primary aldosteronism contributes to kidney disease and heart risk in people with diabetes.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11349753

• Understanding why primary aldosteronism screening is missing or delayed

  A Mayo Clinic-led study aims to understand why many people at risk for primary aldosteronism are not being screened early enough and what can be done to fix it.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11291330

• Investigating how unrecognized primary aldosteronism contributes to kidney disease in diabetes

  This study is looking at how a condition called primary aldosteronism might affect kidney health in people with diabetes, and it aims to find those who may not know they have it so they can get the right care to protect their kidneys.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11190882

• Investigating the reasons for low and delayed screening of primary Aldosteronism

  This study is looking into why not enough people at risk for primary aldosteronism get tested for it, even though it can cause serious health problems, and it aims to find ways to make screening easier and more accessible for everyone.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11048613

• Investigating the causes and effects of primary aldosteronism subtypes

  This study is looking at primary aldosteronism, a condition that causes high blood pressure, to find better ways to diagnose it using blood tests and tissue samples, so patients can get the right treatment without needing invasive procedures.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11031933

• Investigating heart function and blood flow in patients with primary aldosteronism.

  This study is looking at how a condition called primary aldosteronism impacts heart health in people with heart failure and how a specific type of medication might help improve their heart function by reducing inflammation, so we can find out who might benefit the most from this treatment.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11013901

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.