Understanding heart function and structure in patients with primary aldosteronism
(Administrative Supplement) Cardiac Perfusion, Structure, and Function across the Primary Aldosteronism Spectrum
This study is looking at how primary aldosteronism impacts heart health in people with heart failure that still pumps well, and it will explore how a medication called spironolactone might help improve their heart function and structure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11200687 on NIH RePORTER |
What this research studies
This research investigates how primary aldosteronism affects heart function and structure, particularly in patients with heart failure with preserved ejection fraction (HFpEF). It aims to explore the mechanisms by which mineralocorticoid receptor antagonists, like spironolactone, can improve heart health in these patients. The study will involve assessing cardiac perfusion, structure, and function through advanced imaging techniques and clinical evaluations. By understanding these relationships, the research seeks to identify better treatment strategies for those affected by this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary aldosteronism, particularly those experiencing heart failure with preserved ejection fraction.
Not a fit: Patients without primary aldosteronism or those not experiencing heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with heart failure and primary aldosteronism, potentially reducing cardiovascular risks.
How similar studies have performed: Previous research has shown promising results with mineralocorticoid receptor antagonists in similar patient populations, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Brown, Jenifer Michelle — Brigham and Women's Hospital
- Study coordinator: Brown, Jenifer Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.