Investigating the causes and effects of primary aldosteronism subtypes
Official title: Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures
Funded at University of Michigan at Ann Arbor · NIH-11031933 · Data updated 2026-11-12
This study is looking at primary aldosteronism, a condition that causes high blood pressure, to find better ways to diagnose it using blood tests and tissue samples, so patients can get the right treatment without needing invasive procedures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 7, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $608,559 |
| NIH project number | 5R01HL155834-05 |
| Project ID | NIH-11031933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with primary aldosteronism, particularly those who may benefit from improved diagnostic techniques.
✕Less likely to help
Patients with primary aldosteronism who have already undergone successful treatment or those with other unrelated adrenal disorders may not benefit from this research.
What this research studies
This research focuses on primary aldosteronism (PA), a common adrenal disorder that leads to high blood pressure and serious cardiovascular issues. The study aims to better understand the different types of PA by analyzing tissue samples and blood tests to identify specific steroid signatures. By improving diagnostic methods, the research seeks to reduce the need for invasive procedures currently used to subtype PA, making it easier for patients to receive accurate diagnoses and appropriate treatments. Ultimately, this work could lead to more effective management of PA and its associated health risks.
Why it matters
Potential benefit: If successful, this research could provide patients with a less invasive and more accurate way to diagnose and manage primary aldosteronism.
How similar studies have gone: Previous research has shown promise in improving diagnostic methods for adrenal disorders, suggesting that this approach may lead to significant advancements in the field.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Turcu, Adina F — University of Michigan at Ann Arbor
- Study coordinator: Turcu, Adina F
Related research
Other NIH-funded projects on the same topics.
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Unrecognized Primary Aldosteronism and Kidney Disease in Diabetes
A study at Brigham and Women’s Hospital will explore whether unrecognized primary aldosteronism contributes to kidney disease and heart risk in people with diabetes.
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Understanding why primary aldosteronism screening is missing or delayed
A Mayo Clinic-led study aims to understand why many people at risk for primary aldosteronism are not being screened early enough and what can be done to fix it.
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Understanding heart function and structure in patients with primary aldosteronism
This study is looking at how primary aldosteronism impacts heart health in people with heart failure that still pumps well, and it will explore how a medication called spironolactone might help improve their heart function and structure.
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Investigating how unrecognized primary aldosteronism contributes to kidney disease in diabetes
This study is looking at how a condition called primary aldosteronism might affect kidney health in people with diabetes, and it aims to find those who may not know they have it so they can get the right care to protect their kidneys.
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Investigating the reasons for low and delayed screening of primary Aldosteronism
This study is looking into why not enough people at risk for primary aldosteronism get tested for it, even though it can cause serious health problems, and it aims to find ways to make screening easier and more accessible for everyone.
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Investigating heart function and blood flow in patients with primary aldosteronism.
This study is looking at how a condition called primary aldosteronism impacts heart health in people with heart failure and how a specific type of medication might help improve their heart function by reducing inflammation, so we can find out who might benefit the most from this treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.