Comparing two treatments for primary aldosteronism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the efficacy and safety of adrenalectomy versus superselective adrenal artery embolization in patients diagnosed with primary aldosteronism. It is a prospective, multicenter, randomized controlled trial designed to evaluate these two interventional therapies as alternatives for treating this condition. Primary aldosteronism is a significant cause of secondary hypertension, and the study seeks to provide insights into the best treatment options available. The research will involve patients aged 18 to 60 who meet specific diagnostic criteria for the condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-60
* Diagnosed with primary aldosteronism according to the 2016 Clinical guidelines of the International Endocrine Society
* Primary aldosteronism diagnosed according to international guidelines Unilateral disease by AVS or PET-CT criteria
* Patients and their family members signed informed consent and agreed to participate in the study

Exclusion Criteria:

* A history of severe hypersensitivity to contrast media
* Severe liver disease complications, such as thrombocytopenia, esophageal varices rupture bleeding, etc
* Renal insufficiency (serum creatinine \> 176mmol/L or estimated glomerular filtration rate \< min.1.73m2)
* Combined with other secondary hypertension, such as pheochromocytoma, hypercortisolism, renal vascular hypertension (such as renal artery stenosis), renin secretory tumor, renal parenchymatous hypertension, drug-induced hypertension (such as long-term use of glucocorticoids, contraceptives, estrogen, herbal medicines containing glycyrrhizin), pregnancy hypertension and other secondary hypertension
* Combined with genetic diseases: such as false aldosteronism (Liddle syndrome), Bartter syndrome, familial hypokalemia and hypomagnesia (Gitelman syndrome)
* Stroke, myocardial infarction and stent implantation occurred in the past 3 months
* Serious other diseases, such as heart dysfunction (grade IV), acute infections, autoimmune diseases, various malignant tumors, etc
* Participated in other clinical trials within the past 3 months
* Pregnant, breastfeeding, or planning a pregnancy
* Identify patients with alcohol allergy

Where it's running

• The First Affiliated Hospital of Xinjiang Medical University
  Ürümqi, Xinjiang, China Recruiting

Study contacts

• Study coordinator: Xiang Xie, PhD
• Email: xiangxie999@sina.com
• Phone: +869914366892

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.