Evaluating adrenal insufficiency after surgery in patients with primary aldosteronism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the incidence of adrenal insufficiency following adrenalectomy in patients diagnosed with primary aldosteronism, both with and without concurrent autonomous cortisol secretion. Participants will undergo a complete ACTH stimulation test the day after their surgery to evaluate their adrenal function. The study will follow these patients for a period of 6 to 12 months post-surgery to monitor any occurrences of adrenal insufficiency. It is a single-center study conducted at the First Affiliated Hospital of Chongqing Medical University.

Why it matters

Who can join: the full rules

* A confirmed diagnosis of primary aldosteronism or autonomous cortisol secretion;

  ② Completion of unilateral adrenal surgery;

  ③ Voluntary participation and obtaining informed consent. (2) Exclusion criteria
* Patients with typical clinical manifestations of Cushing's syndrome;

  * Patients suspected of having bilateral cortisol over-secretion, such as PBMAH or PPNAD; ③ Patients with severe surgical complications, unstable postoperative condition (not due to cortical insufficiency), and difficulty completing the ACTH stimulation test;

    * History of ACTH allergy;

      * Patients requiring long-term hormone therapy for other diseases (such as autoimmune diseases);

        * Severe liver and kidney dysfunction (ALT ≥ 3 times the upper limit of normal; patients undergoing dialysis or with an estimated glomerular filtration rate \< 30 ml/min/m2); ⑦ History of contralateral adrenal surgery; ⑧ Patients with poor compliance who are unable to complete the study.

Where it's running

• the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  Chongqing, Chongqing Municipality, China Recruiting

Study contacts

• Study coordinator: Li Qifu, PhD
• Email: liqifu@yeah.net
• Phone: +86-023-89011552

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• Metomidate PET-CT vs Usual Care for Primary Aldosteronism

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.