Captopril Test with LC-MS/MS for Aldosterone and Renin in Primary Aldosteronism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares aldosterone measurements by LC-MS/MS to conventional methods during the captopril inhibition test to establish a more precise diagnostic cutoff for primary aldosteronism. It will include healthy volunteers and patients suspected of PA to determine an improved threshold. The goal is to improve diagnostic accuracy and help clinicians identify and treat PA earlier. The study uses a standardized captopril test protocol and analyzes aldosterone and renin activity to refine the diagnostic criteria.

Why it matters

Who can join: the full rules

Normal Control Group

Inclusion Criteria

* Age 18-70 years old
* BMI: 18.5-23.9kg/m²
* Gender not restricted
* Blood pressure: 100-120/60-80mmHg
* No history of hypertension
* No abnormal nodules found in adrenal CT
* Previous blood potassium and electrocardiogram were all within normal ranges
* No history of liver or kidney dysfunction, malignant tumors, metabolic diseases or cardiovascular diseases
* No medication used

Exclusion Criteria

* Those with a family history of hypertension or with clinical manifestations of secondary hypertension
* Those who have been taking drugs that may affect the RAAS system for a long time (such as contraceptives, steroids, etc.)
* Those with cardiac dysfunction or severe arrhythmia and unable to tolerate the test

Patients with suspected primary aldosteronism

Inclusion Criteria:

* Patients with suspected primary aldosteronism in the outpatient setting
* Willing to undergo 4-week spironolactone treatment and cooperate with follow-up

Exclusion Criteria:

* Patients who did not complete the captopril suppression test
* Patients with Cushing's syndrome or other endocrine tumors
* Patients allergic to spironolactone or with contraindications for its use (such as severe hyperkalemia, eGFR \< 30)
* History of liver or kidney dysfunction
* Coexisting severe cardiovascular or cerebrovascular diseases
* History of malignant tumors
* Other types of endocrine hypertension (hyperthyroidism, pheochromocytoma, Cushing's syndrome, etc.)
* Renal artery stenosis
* Hypokalemia caused by other factors (renal tubular acidosis, Bartter syndrome, Gitelman syndrome, etc.)
* Diabetes with HbA1c \> 7.0% or currently using or having used insulin or SGLT2 inhibitor drugs
* Taking special medications such as glucocorticoids, immunosuppressants, oral contraceptives, etc

Where it's running

• Peking Union Medical Colledge Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Tong Anli
• Email: tonganli@hotmail.com
• Phone: +8613460884085

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.