Using renin levels to guide treatment with mineralocorticoid receptor antagonists for Primary Aldosteronism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the feasibility of using renin measurements to guide the treatment of patients with Primary Aldosteronism (PA) who are prescribed mineralocorticoid receptor antagonists (MRA). It aims to determine if elevated renin levels during MRA treatment can indicate effective aldosterone blockade and help tailor dosing for individual patients. The study will include adults diagnosed with PA who are starting long-term MRA therapy, while monitoring their renin levels to assess treatment response. The goal is to improve treatment outcomes and minimize side effects associated with MRA therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Over 18 years of age
* Diagnosis of PA, in accordance with clinical guidelines and local practice
* Suppressed plasma renin prior to treatment initiation (plasma renin concentration \>15 mIU/L or \>10 ng/L, or plasma renin activity \>1 ng/mL/h)
* Planned long-term treatment with mineralocorticoid receptor antagonist

Exclusion Criteria:

* Prior use of mineralocorticoid receptor antagonist or any potassium-sparing diuretics in the past 3 months
* Known intolerance or contraindication to mineralocorticoid receptor antagonist treatment
* eGFR \< 30 ml/min/1.73m2 (past 3 months)
* Baseline serum potassium above \> 4.8 mmol/L (past 3 months)
* Deemed medically unsafe to stop medications for the initiation of MRA as monotherapy
* Pregnancy or breastfeeding
* Participation in another study that is likely to affect renin or BP levels
* Inability to provide consent due to cognitive impairment and/or language barrier.

Where it's running

• Hôpital du Sacré-Coeur de Montréal
  Montreal, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Remi Goupil, MD MSc
• Email: remi.goupil@umontreal.ca
• Phone: 1(514)338-2883

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.