Long-term outcomes after treatment for primary aldosteronism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter prospective cohort enrolling adults with biochemically confirmed primary aldosteronism at two major hospitals in China. Investigators will collect baseline clinical features, etiologic subtypes, diagnostic approaches, and treatment plans, then perform standardized follow-up visits over five years. The study will compare short-term treatment responses and long-term prognosis across pathological subtypes (for example adrenal adenoma versus hyperplasia) and treatment modalities including medication and surgery. Outcomes include rates of blood pressure and hormonal normalization, trajectories of cardiac, renal and vascular damage, metabolic and cognitive changes, and predictors of cardiovascular events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged between 18 and 80 years old.
2. Biochemically confirmed diagnosis of Primary Aldosteronism (PA) according to contemporary guidelines (e.g., confirmed positive case detection test and confirmatory test).
3. Voluntary to sign the informed consent.

Exclusion Criteria:

1. patients with severe cardiac, hepatic or renal dysfunction;
2. Diagnosis of secondary hypertension other than PA.

Where it's running

• The First Affiliated Hospital of Chengdu Medical College
  Chengdu, Sichuan, China Recruiting
• The First Affiliated Hospital of Xinjiang Medical University
  Ürümqi, Xinjiang, China Recruiting

Study contacts

• Study coordinator: Xiang Xie, PhD
• Email: xiangxie999@sina.com
• Phone: +86-991-4366892

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.