Investigating heart function and blood flow in patients with primary aldosteronism.
Cardiac Perfusion, Structure, and Function across the Primary Aldosteronism Spectrum
This study is looking at how a condition called primary aldosteronism impacts heart health in people with heart failure and how a specific type of medication might help improve their heart function by reducing inflammation, so we can find out who might benefit the most from this treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11013901 on NIH RePORTER |
What this research studies
This research focuses on understanding how primary aldosteronism affects heart function and blood flow, particularly in patients with heart failure with preserved ejection fraction (HFpEF). It aims to explore the mechanisms by which mineralocorticoid receptor antagonists, a type of medication, can improve heart health by reducing inflammation and other harmful processes. By analyzing various patient data, the study seeks to identify which patients may benefit most from these treatments, potentially leading to more personalized care.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with primary aldosteronism or those experiencing hypertension related to heart failure.
Not a fit: Patients without hypertension or heart failure, or those not diagnosed with primary aldosteronism, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with heart failure and hypertension, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results with mineralocorticoid receptor antagonists in treating heart failure, indicating potential for success in this study as well.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Brown, Jenifer Michelle — Brigham and Women's Hospital
- Study coordinator: Brown, Jenifer Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.