Investigating heart function and blood flow in patients with primary aldosteronism.
Official title: Cardiac Perfusion, Structure, and Function across the Primary Aldosteronism Spectrum
Funded at Brigham and Women's Hospital · NIH-11013901 · Data updated 2026-11-12
This study is looking at how a condition called primary aldosteronism impacts heart health in people with heart failure and how a specific type of medication might help improve their heart function by reducing inflammation, so we can find out who might benefit the most from this treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 15, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $192,896 |
| NIH project number | 5K23HL159279-04 |
| Project ID | NIH-11013901 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with primary aldosteronism or those experiencing hypertension related to heart failure.
✕Less likely to help
Patients without hypertension or heart failure, or those not diagnosed with primary aldosteronism, may not benefit from this research.
What this research studies
This research focuses on understanding how primary aldosteronism affects heart function and blood flow, particularly in patients with heart failure with preserved ejection fraction (HFpEF). It aims to explore the mechanisms by which mineralocorticoid receptor antagonists, a type of medication, can improve heart health by reducing inflammation and other harmful processes. By analyzing various patient data, the study seeks to identify which patients may benefit most from these treatments, potentially leading to more personalized care.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with heart failure and hypertension, enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results with mineralocorticoid receptor antagonists in treating heart failure, indicating potential for success in this study as well.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Brown, Jenifer Michelle — Brigham and Women's Hospital
- Study coordinator: Brown, Jenifer Michelle
Related research
Other NIH-funded projects on the same topics.
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Unrecognized Primary Aldosteronism and Kidney Disease in Diabetes
A study at Brigham and Women’s Hospital will explore whether unrecognized primary aldosteronism contributes to kidney disease and heart risk in people with diabetes.
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Understanding why primary aldosteronism screening is missing or delayed
A Mayo Clinic-led study aims to understand why many people at risk for primary aldosteronism are not being screened early enough and what can be done to fix it.
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Understanding heart function and structure in patients with primary aldosteronism
This study is looking at how primary aldosteronism impacts heart health in people with heart failure that still pumps well, and it will explore how a medication called spironolactone might help improve their heart function and structure.
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Investigating how unrecognized primary aldosteronism contributes to kidney disease in diabetes
This study is looking at how a condition called primary aldosteronism might affect kidney health in people with diabetes, and it aims to find those who may not know they have it so they can get the right care to protect their kidneys.
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Investigating the reasons for low and delayed screening of primary Aldosteronism
This study is looking into why not enough people at risk for primary aldosteronism get tested for it, even though it can cause serious health problems, and it aims to find ways to make screening easier and more accessible for everyone.
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Investigating the causes and effects of primary aldosteronism subtypes
This study is looking at primary aldosteronism, a condition that causes high blood pressure, to find better ways to diagnose it using blood tests and tissue samples, so patients can get the right treatment without needing invasive procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.