Condition

Pre-Eclampsia clinical trials and research

• 38Clinical trials
• 6NIH research projects
• 16Countries

Newest Pre-Eclampsia clinical trials

All recruiting trials (38)

• Preeclampsia Biomarker Test in African Women

  This study tests whether measuring the sFlt-1/PlGF ratio using quick clinic tests helps predict which pregnant women in Africa will develop severe preeclampsia.

  Recruiting Africa Clinical Research Network (ACRN) · Harare, Harare · NCT07810439

• Internal jugular vein collapsibility to gauge volume status in preeclampsia vs. normal pregnancy

  This study tests whether ultrasound of the internal jugular vein can show differences in fluid status between preeclamptic pregnant people and those with normal blood pressure during planned cesarean delivery.

  Recruiting Tanta University · Tanta, El-Gharbia Govenorate · NCT07786246

• Blood pressure checker Withings BPM Pro 2 in pregnancy

  This study tests whether the Withings BPM Pro 2 blood pressure monitor gives accurate readings for pregnant people, including those with high blood pressure or preeclampsia.

  Recruiting Withings · Yerevan, Armenia · NCT07595016

• How the placenta affects maternal and fetal health

  This project will test whether tiny particles released by the placenta differ in pregnancies with pre-eclampsia, gestational diabetes, or fetal growth restriction compared with healthy pregnancies and non-pregnant women.

  Recruiting University of Oxford · Oxford · NCT07470320

• Vitamin D to prevent recurrent pre-eclampsia in pregnant women

  This study will test whether taking 4,000 IU of vitamin D during pregnancy lowers the chance of pre-eclampsia returning in women who had it in a prior pregnancy.

  Recruiting Phase 4 Nishtar Medical University · Multan, Punjab Province · NCT07288801

• Pre-eclampsia risk in pregnancies after oocyte donation

  We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.

  Recruiting at 6 sites Copenhagen University Hospital, Hvidovre · Copenhagen and 5 other locations · NCT07263490

• Pre-eclampsia risk in pregnancies after oocyte donation

  We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.

  Recruiting at 6 sites Copenhagen University Hospital, Hvidovre · Copenhagen and 5 other locations · NCT07263490

• Pre-eclampsia risk in pregnancies after oocyte donation

  We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.

  Recruiting at 6 sites Copenhagen University Hospital, Hvidovre · Copenhagen and 5 other locations · NCT07263490

• Oxford study on the corpus luteum and placental health in early pregnancy

  This observational study tests whether markers from the corpus luteum in early pregnancy can help predict who will develop preeclampsia.

  Recruiting University of Oxford · Oxford · NCT07072052

• Remote monitoring and education for postpartum blood pressure management

  This study is testing if a program that combines remote blood pressure monitoring and education with daily text reminders can help new moms manage high blood pressure after giving birth.

  Recruiting Ochsner Health System · New Orleans, Louisiana · NCT06920563

• Virtual reality versus in-person progressive muscle relaxation for pregnant people with preeclampsia

  This trial will test whether virtual reality–guided progressive muscle relaxation or face-to-face progressive muscle relaxation better reduces stress and improves maternal and fetal outcomes in hospitalized pregnant people with preeclampsia at or after 26 weeks.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT06893510

• Using natural killer cells from patients to improve fertility and pregnancy outcomes

  This study is testing whether using a special type of immune cell from patients can help improve fertility and pregnancy outcomes for those struggling with infertility or past pregnancy issues.

  Recruiting Phase 1 The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06821685

• Using dapagliflozin to reduce cardiovascular risk after hypertensive pregnancies

  This study is testing if the medication dapagliflozin can help reduce heart risks for women who had high blood pressure during pregnancy after they give birth.

  Recruiting Phase 4 University of Michigan · Ann Arbor, Michigan · NCT06785116

• Autophagy and cell-death balance in placenta-related pregnancy complications

  This observational project will test whether changes in autophagy and apoptosis in the placenta are linked to pre-eclampsia or intrauterine growth restriction in pregnant women delivering at Nîmes University Hospital.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06779916

• Ultrasound assessment of airway difficulties in critically ill preeclamptic patients

  This study tests if using two or five ultrasound views can better predict airway difficulties during cesarean sections for critically ill pregnant women with preeclampsia compared to standard methods.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT06651879

• Use of metformin to prolong pregnancy in preterm preeclampsia in the Netherlands

  In pregnant people with preterm preeclampsia, this study tests whether metformin can help them stay pregnant longer compared with placebo.

  Recruiting Phase 3 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06452498

• Use of metformin to prolong pregnancy in preterm preeclampsia in the Netherlands

  In pregnant people with preterm preeclampsia, this study tests whether metformin can help them stay pregnant longer compared with placebo.

  Recruiting Phase 3 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06452498

• Use of metformin to prolong pregnancy in preterm preeclampsia in the Netherlands

  In pregnant people with preterm preeclampsia, this study tests whether metformin can help them stay pregnant longer compared with placebo.

  Recruiting Phase 3 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06452498

• Study of Twin Pregnancies and Their Outcomes in China

  This study is trying to understand the challenges and outcomes of twin pregnancies in China by following 2000 pregnant women and their babies from pregnancy through early childhood.

  Recruiting at 11 sites Peking University Third Hospital · Hefei, Anhui and 10 other locations · NCT06414655

• Using aspirin to prevent pregnancy loss and preeclampsia

  This study is testing if starting low-dose aspirin early in pregnancy can help women at risk for pregnancy loss and preeclampsia have healthier pregnancies.

  Recruiting Phase 3 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06408181

• Understanding maternal health after preeclampsia

  This study is trying to find out how to help new moms who had preeclampsia stay healthy and avoid heart problems after giving birth.

  Recruiting University of California, San Diego · San Diego, California · NCT06340152

• Exercise to Reduce PreEclampsia Risk in Pregnant Women

  This study is testing whether different types of exercise can help pregnant women at risk for preeclampsia have healthier pregnancies and better outcomes for their babies.

  Recruiting East Carolina University · Greenville, North Carolina · NCT06319014

• Investigating the role of anti-C1q autoantibodies in pregnancy complications

  This study is trying to see if certain antibodies in the blood are linked to pregnancy complications like pre-eclampsia in women.

  Recruiting IRCCS Burlo Garofolo · Trieste · NCT06317467

• Using low-dose aspirin after preeclampsia to improve recovery

  This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06281665

• Identifying Women at Risk for Placental Dysfunction

  This study is trying to see if a new tool can help identify pregnant women at risk for placental problems by looking at their health information and blood tests.

  Recruiting Oulu University Hospital · Oulu · NCT06115122

• Weight loss program for patients who had pre-eclampsia

  This study is testing two different diet plans to help overweight women who had pre-eclampsia lose weight while keeping their muscle, to see which one works better for their health.

  Recruiting Centre Hospitalier le Mans · Le Mans · NCT06067906

• Understanding pre-eclampsia risk in patients using assisted reproductive technology

  This study is trying to understand the risk of pre-eclampsia in women with polycystic ovary syndrome who are using assisted reproductive technology to help improve their pregnancy care and outcomes.

  Recruiting CRG UZ Brussel · Brussels · NCT05746793

• Understanding postpartum pulmonary artery pressure in women with preeclampsia and antiphospholipid syndrome

  This study looks at the heart health of women who had high blood pressure during pregnancy and also have a specific blood condition, to see how these issues affect them after childbirth.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT05679206

• Comparing microvesicles in pregnant women with and without pre-eclampsia

  This study is testing if the tiny particles in the blood of pregnant women can help tell the difference between those with severe pre-eclampsia and those without it.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT05675969

• Using aspirin to prevent preeclampsia in women after assisted reproductive technology

  This study is testing if taking aspirin during early pregnancy can help prevent preeclampsia in women who are at high risk and became pregnant through assisted reproductive technology.

  Recruiting at 19 sites Phase 3 University Hospital, Toulouse · Angers and 20 other locations · NCT05625724

• Investigating cardiovascular risks in women after complicated pregnancies

  This study looks at how having high blood pressure during pregnancy might affect women's heart health later on and whether certain blood tests can help predict their risk for heart problems.

  Recruiting Maastricht University Medical Center · Maastricht · NCT05500989

• Testing a form of folate in pregnancy for women with high blood pressure

  This trial will test whether giving a biologically active folate (5‑MTHF) to pregnant women with pre-eclampsia or pregnancy-induced high blood pressure can raise a blood-vessel support molecule (BH4) and help mothers and babies.

  Recruiting at 2 sites University of Oxford · Oxford, Oxfordhsire and 1 other locations · NCT05434195

• Predicting preeclampsia early using arterial stiffness in high-risk pregnancies

  This study is testing a new way to spot early signs of preeclampsia in high-risk pregnancies by measuring how stiff blood vessels are, along with other tests, to help improve care for moms and babies.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04783597

• Predicting progression from gestational hypertension to preeclampsia in pregnant women

  This study is trying to find out if certain blood vessel markers can help predict if pregnant women with gestational hypertension will develop preeclampsia.

  Recruiting at 3 sites Assistance Publique - Hôpitaux de Paris · Bobigny, Seine Saint Denis and 2 other locations · NCT04520048

• Using aspirin to prevent complications in pregnant women with chronic hypertension

  This study is testing whether taking low-dose aspirin during pregnancy can help prevent serious complications for women with chronic high blood pressure and their babies.

  Recruiting at 14 sites Phase 3 Centre Hospitalier Intercommunal Creteil · Bordeaux and 19 other locations · NCT04356326

• Investigating blood vessel changes during pregnancy

  This study is trying to see how blood vessels change during pregnancy in women with and without preeclampsia by looking at tissue samples taken during cesarean sections.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT03806283

• How the placenta, blood, and urine samples can help us understand preeclampsia and growth problems in pregnancy

  This study collects placenta, blood, and urine samples at delivery from pregnant women to help researchers understand preeclampsia and fetal growth restriction.

  Recruiting Centre Hospitalier Intercommunal Creteil · Créteil · NCT03626233

• Investigation of pre-eclampsia in pregnant women

  This study is testing new ways to monitor pregnant women at high risk for pre-eclampsia to see if it can help catch the condition early and improve treatment.

  Recruiting at 8 sites Hasselt University · Bree and 7 other locations · NCT03509272

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• mRNA lipid nanoparticles to treat pre-eclampsia

  A new approach uses tiny delivery particles to send therapeutic mRNA to the placenta in pregnancy-related high blood pressure to help both mother and baby.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11378526

• Heart function during and after pre-eclampsia

  This project looks at how severe pre-eclampsia affects heart function in pregnant women from different racial backgrounds by checking heart health at delivery and up to a year later and linking findings to genetic differences.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11258930

• New mRNA treatment for pre-eclampsia

  This project aims to create a new mRNA treatment delivered by tiny particles to help manage pre-eclampsia during pregnancy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11166526

• Investigating heart function in women with severe pre-eclampsia during and after pregnancy

  This study is looking at how severe pre-eclampsia affects heart health in women from different racial backgrounds, checking their heart function during delivery and again at 6 and 12 months after giving birth, to help find better ways to support women who might be at risk based on their genetics.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11049303

• Using mRNA lipid nanoparticles to treat pre-eclampsia

  This study is testing a new way to treat pre-eclampsia during pregnancy by using tiny particles to deliver helpful messages to the placenta, with the goal of improving blood flow and lowering high blood pressure, so that both moms and babies can be healthier.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10946273

• A new tool for quickly measuring a key protein to help detect pre-eclampsia in pregnant women.

  This study is working on a quick and easy test to check for a substance called Placental Growth Factor (PlGF) that helps predict pre-eclampsia in pregnant women, making it easier for doctors to spot and treat this serious condition early on.

  NIH research Ricovr Healthcare INC. · Princeton, United States · NIH-10820752

Related topics

Quick answers

How many Pre-Eclampsia clinical trials are recruiting right now?

38, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (7 trials), France (7 trials), Netherlands (4 trials), United Kingdom (3 trials), Denmark (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 6, Phase 4: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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