Clinical trial Recruiting at 1 site Interventional Ages 18 to 40 Women only

Exercise to Reduce PreEclampsia Risk in Pregnant Women

Official title: Physical Activity to Mitigate PreEclampsia Risk (PAMPER)

Run by East Carolina University · NCT06319014 · Data updated 2026-11-12

This study is testing whether different types of exercise can help pregnant women at risk for preeclampsia have healthier pregnancies and better outcomes for their babies.

More Pre-Eclampsia trials

Quick facts

Study typeInterventional
Ages18 Years to 40 Years
SexWomen only
Enrollment224 (estimated)
SponsorEast Carolina University
Academic / other
Locations1 site (Greenville, North Carolina)
StatusRecruiting
StartedJune 24, 2024
Main results expectedDecember 1, 2027
Study endsDecember 1, 2027
Registry record updatedSeptember 11, 2026
Trial IDNCT06319014 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are healthy women aged 18-40 years, less than 16 weeks pregnant, with a singleton pregnancy and a BMI between 18.5 and 45.0.

Probably not a fit

Patients with pre-existing chronic conditions or those taking medications that affect fetal development may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effects of different types of exercise—aerobic, resistance, and a combination of both—on maternal and fetal health in women at risk for preeclampsia. The researchers will assess how these exercise modes influence maternal cardiometabolic health and birth outcomes throughout pregnancy. By monitoring various physiological variables, the study seeks to determine which exercise regimen is most effective in reducing the severity and occurrence of preeclampsia symptoms. The ultimate goal is to improve health outcomes for both mothers and their infants.

Why it matters

Potential benefit: If successful, this study could lead to improved health outcomes for pregnant women and their infants by reducing the risk and severity of preeclampsia.

How similar studies have gone: Preliminary data from other studies suggest that exercise may help mitigate the severity and risk of preeclampsia, indicating potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* healthy women, age 18-40 years, \<16 weeks' gestation, with singleton pregnancy; women (BMI:18.5-45.0), sedentary, cleared by their obstetric provider.

Exclusion Criteria:

* pre-existing chronic conditions such as HIV, lupus, etc.; taking medicines that affect fetal development; and/or lack of telephone or email contact information).

Where it's running

  • East Carolina University
    Greenville, North Carolina, United States
    Recruiting

Study contacts

  • Principal investigator: Linda E May, MS, PhD — East Carolina University
  • Study coordinator: Linda E May, MS, PhD
  • Email: mayl@ecu.edu
  • Phone: 2527377072

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Pre-eclampsia risk in pregnancies after oocyte donation

    We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.

    Recruiting at 6 sites Copenhagen University Hospital, Hvidovre · Copenhagen and 5 other locations · NCT07263490

  • Use of metformin to prolong pregnancy in preterm preeclampsia in the Netherlands

    In pregnant people with preterm preeclampsia, this study tests whether metformin can help them stay pregnant longer compared with placebo.

    Recruiting Phase 3 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06452498

  • Preeclampsia Biomarker Test in African Women

    This study tests whether measuring the sFlt-1/PlGF ratio using quick clinic tests helps predict which pregnant women in Africa will develop severe preeclampsia.

    Recruiting Africa Clinical Research Network (ACRN) · Harare, Harare · NCT07810439

  • Internal jugular vein collapsibility to gauge volume status in preeclampsia vs. normal pregnancy

    This study tests whether ultrasound of the internal jugular vein can show differences in fluid status between preeclamptic pregnant people and those with normal blood pressure during planned cesarean delivery.

    Recruiting Tanta University · Tanta, El-Gharbia Govenorate · NCT07786246

  • Blood pressure checker Withings BPM Pro 2 in pregnancy

    This study tests whether the Withings BPM Pro 2 blood pressure monitor gives accurate readings for pregnant people, including those with high blood pressure or preeclampsia.

    Recruiting Withings · Yerevan, Armenia · NCT07595016

  • How the placenta affects maternal and fetal health

    This project will test whether tiny particles released by the placenta differ in pregnancies with pre-eclampsia, gestational diabetes, or fetal growth restriction compared with healthy pregnancies and non-pregnant women.

    Recruiting University of Oxford · Oxford · NCT07470320

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.