Predicting progression from gestational hypertension to preeclampsia in pregnant women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to identify vascular biomarkers that can predict the progression of gestational hypertension to preeclampsia in pregnant women. It involves measuring urinary endothelial microparticles, aortic central pressure, carotid-femoral pulse wave velocity, and vascular biomarker assays. The study focuses on women between 18 and 40 years old who are experiencing gestational hypertension or preeclampsia between the 20th and 26th weeks of pregnancy. By understanding the underlying mechanisms and biomarkers, the study seeks to improve management and outcomes for affected pregnancies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with a hypertension disorder in pregnancy and/or preeclampsia from the 20th amenorrhea week until the 26th ± 2 amenorrhea week.
* Age between 18 and 40 years old.
* Having given written consent.
* Patients affiliated to a social security scheme.

Exclusion Criteria:

* Presence of pathologies interfering in a major way with vascular parameters: known multicomplicated diabetes treated before pregnancy, hypercholesterolemia known (or LDL\>130 mg/dl), multicomplicated connectivitis, proven cardiovascular disease (ischemic heart disease, stroke, arteriopathy of the lower limbs, heart failure), pre-existing known renal failure (serum creatinine \>125 µmol/L) and/or pre-existing proteinuria ≥ 300 mg/24h).
* Cardiac arrhythmia.
* Hepatitis C, HIV infection (assay performed within 6 months prior to diagnosis of pre-eclampsia).
* Recent history of venous (pulmonary embolism, phlebitis) or arterial (myocardial infarction, unstable angina, stroke, transient ischemic attack), thrombotic event ≤ 3 months.
* Patient already engaged in a therapeutic protocol.
* Patients under legal protective measures.
* Patients receiving State Medical Assistance.

Where it's running

• AP-HP Avicenne Hospital, Department of internal medicine
  Bobigny, Seine Saint Denis, France Recruiting
• AP-HP Jean Verdier Hospital, Gynecology and Obstetrics Department
  Bondy, Seine Saint Denis, France Recruiting
• AP-HP Laribosière Hospital, Gynecology and Obstetrics Department
  Paris, France Recruiting

Study contacts

• Principal investigator: Marilucy LOPEZ-SUBLET, MD — AP-HP Avicenne Hospital, Department of Internal Medicine, ESH Hypertension European Excellence Centre
• Study coordinator: Marilucy LOPEZ-SUBLET, MD
• Email: marilucy.lopez-sublet@aphp.fr
• Phone: +33 (0)148955391

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.