Clinical trial Recruiting at 11 sites Observational Ages 18 to 45 Women only

Study of Twin Pregnancies and Their Outcomes in China

Official title: Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China

Run by Peking University Third Hospital · NCT06414655 · Data updated 2026-11-12

This study is trying to understand the challenges and outcomes of twin pregnancies in China by following 2000 pregnant women and their babies from pregnancy through early childhood.

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Quick facts

Study typeObservational
Ages18 Years to 45 Years
SexWomen only
Enrollment2000 (estimated)
SponsorPeking University Third Hospital
Academic / other
Locations11 sites (Hefei, Anhui and 10 other locations)
StatusRecruiting
StartedMarch 1, 2024
Main results expectedNovember 30, 2026
Study endsNovember 30, 2026
Registry record updatedMay 16, 2024
Trial IDNCT06414655 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are women aged 18-45 years who are expecting twins and are less than 14 weeks pregnant.

Probably not a fit

Patients with serious maternal illnesses or mental disorders that prevent participation will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The ChiTwiMC cohort is a multicenter prospective study focusing on the complications associated with twin pregnancies in China. It aims to establish a large mother-child cohort that follows participants from pregnancy through early childhood, collecting extensive data on maternal and neonatal outcomes. The study will recruit 2000 pregnant women aged 18-45 years from nine major university-affiliated hospitals, with data collection occurring at various stages of pregnancy and after delivery. Biological samples will also be collected to investigate adverse outcomes related to twin pregnancies.

Why it matters

Potential benefit: If successful, this study could improve understanding and management of complications in twin pregnancies, leading to better maternal and neonatal health outcomes.

How similar studies have gone: While there have been studies on twin pregnancies, this specific multicenter approach with a comprehensive biobank is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Twin pregnancies
* Female aged between 18-45 years
* Gestational age is less than 14 weeks
* Planning to receive prenatal healthcare and delivery service at the study hospital
* Signing informed concent and willing to participate

Exclusion Criteria:

* Women with mental disorders or serious maternal illness that is not eligible to participate
* Inability to provide informed consent
* Pregnant women not registered in our hospital

Where it's running

  • The First Affiliated Hospital of Anhui Medical University
    Hefei, Anhui, China
    Recruiting
  • Peking University Third Hospital
    Beijing, Beijing Municipality, China
    Recruiting
  • Peking University
    Beijing, Beijing Municipality, China
    Recruiting
  • Chongqing Medical University
    Chongqing, Chongqing Municipality, China
    Recruiting
  • First Affiliated Hospital, Sun Yat-Sen University
    Guangzhou, Guangdong, China
    Recruiting
  • Shengjing Hospital
    Shenyang, Liaoning, China
    Recruiting
Show 5 more locations
  • Shandong Provincial Hospital
    Jinan, Shandong, China
    Recruiting
  • The Second Hospital of Shandong University
    Jinan, Shandong, China
    Recruiting
  • International Peace Maternity and Child Health Hospital
    Shanghai, Shanghai Municipality, China
    Recruiting
  • Shanghai First Maternity and Infant Hospital
    Shanghai, Shanghai Municipality, China
    Recruiting
  • Nankai University
    Tianjin, Tianjin Municipality, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.