Investigating heart function in women with severe pre-eclampsia during and after pregnancy
Official title: SHePREG: Study of Heart function in PRE-Eclampsia during and after PreGnancy
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11049303 · Data updated 2026-11-12
This study is looking at how severe pre-eclampsia affects heart health in women from different racial backgrounds, checking their heart function during delivery and again at 6 and 12 months after giving birth, to help find better ways to support women who might be at risk based on their genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | January 14, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,284,381 |
| NIH project number | 1R01HL173039-01A1 |
| Project ID | NIH-11049303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have experienced severe pre-eclampsia during pregnancy, particularly those from diverse racial backgrounds.
✕Less likely to help
Patients who have not experienced pre-eclampsia or those with unrelated cardiac conditions may not benefit from this research.
What this research studies
This research examines how severe pre-eclampsia affects heart function in women from various racial backgrounds, including Non-Hispanic Black, Non-Hispanic White, Hispanic, and South/Southeast Asian. The study will assess heart function at delivery and again at 6 and 12 months postpartum. By analyzing genetic profiles and potential heart dysfunction, the research aims to understand the long-term cardiac implications of pre-eclampsia. This could lead to tailored interventions for at-risk women based on their genetic backgrounds.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for women experiencing severe pre-eclampsia, ultimately reducing maternal cardiac complications.
How similar studies have gone: Previous research has shown that understanding genetic factors in cardiac conditions can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Bradley, Elisa Ann — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Bradley, Elisa Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.