Comparing microvesicles in pregnant women with and without pre-eclampsia
Official title: Study of Microvesicles in Pre-eclampsia
Run by University Hospital, Bordeaux · NCT05675969 · Data updated 2026-11-12
This study is testing if the tiny particles in the blood of pregnant women can help tell the difference between those with severe pre-eclampsia and those without it.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 20 (estimated) |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Status | Recruiting |
| Started | May 31, 2023 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | February 10, 2025 |
| Trial ID | NCT05675969 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include pregnant women aged 18 and older, between 23 and 31+6 weeks of gestation, with either a diagnosis of severe pre-eclampsia or those hospitalized for isolated threat of preterm delivery without inflammation.
✕Probably not a fit
Patients who are unable to provide informed consent or those under legal protection may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to analyze the concentration of microvesicles in the blood of pregnant women diagnosed with severe pre-eclampsia compared to those without the condition. Microvesicles are membrane fragments released by cells that may serve as biomarkers for various conditions, including pre-eclampsia. The research will utilize advanced techniques such as cryo-electron microscopy and flow cytometry to characterize and quantify these microvesicles. The goal is to better understand the role of microvesicles in pre-eclampsia and their potential as indicators of maternal health during pregnancy.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools for early detection of pre-eclampsia, enhancing maternal and fetal health outcomes.
How similar studies have gone: Previous studies have indicated the potential of microvesicles as biomarkers in pre-eclampsia, suggesting that this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Singleton pregnancy (or spontaneously reduced twin pregnancy before 14 SA) * Gestational age at inclusion between 23 and 31+6 SA * Collection of the patient's non-opposition * Affiliated or beneficiary of a social security system * Specifically for the non-pre-eclampsia group: non-pre-eclamptic patient hospitalized for isolated threat of preterm delivery, whatever the origin, and without clinical (absence of maternal hyperthermia defined by a maternal temperature \< 38.0°C) or biological markers of inflammation (CRP\<5) * Specifically for the pre-eclampsia group : diagnosis of severe pre-eclampsia before 32 weeks' gestation Exclusion Criteria: * Patient's inability to understand the nature, risks, meaning and implications of the clinical investigation or refusal to give consent * Patient under legal protection.
Where it's running
-
CHU Bordeaux
Bordeaux, France Recruiting
Study contacts
- Study coordinator: Loic Sentilhes, MD, PhD
- Email: loic.sentilhes@chu-bordeaux.fr
- Phone: +335 57 82 23 36
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.