Understanding maternal health after preeclampsia
Multi-Omics for Maternal Health After Preeclampsia
This study is trying to find out how to help new moms who had preeclampsia stay healthy and avoid heart problems after giving birth.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1100 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | University of California, San Diego Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (San Diego, California) |
| Trial ID | NCT06340152 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify postpartum women at risk for adverse cardiovascular outcomes following preeclampsia and develop preventative strategies. It will recruit a diverse group of pregnant women, both high- and low-risk for hypertensive disorders, to collect phenotypic, environmental, and multi-omic data. Participants will be enrolled by 24 weeks of gestation and followed for one year postpartum, with data collected through surveys, cardiovascular assessments, and biospecimen analysis. The study will take place at UCSD and VUMC, with options for participants to choose private locations for visits.
Who should consider this trial
Good fit: Ideal candidates are pregnant women aged 18 to 50 years, between 10 to 24 weeks of gestation, with a singleton pregnancy planning to deliver at a study site.
Not a fit: Patients with multi-fetal gestation, significant fetal anomalies, or those who cannot provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved preventative therapies for postpartum women at risk of cardiovascular issues after preeclampsia.
How similar studies have performed: Other studies have shown promise in understanding maternal health post-preeclampsia, but this multi-omics approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women 18 years of age to 50 years of age * 10-24 weeks gestation at time of enrollment * Singleton pregnancy * Planning to deliver at a study site (UCSD or VUMC) Exclusion Criteria: * Inability to give informed consent * Intrauterine fetal demise * Fetal genetic or structural anomaly * Institutionalization for psychiatric disorder, mental deficiency or incarcerated * Active or history of malignancy requiring major surgery or systemic chemotherapy * Multi-fetal gestation or a twin demise at any gestational age * Known maternal or fetal chromosomal anomalies * Patients who plan to keep their placenta after delivery
Where this trial is running
San Diego, California
- University of California, San Diego — San Diego, California, United States (Recruiting)
Study contacts
- Principal investigator: Louise Laurent, MD, PhD — UCSD
- Study coordinator: Maya Selvaraj
- Email: momhealthstudy@health.ucsd.edu
- Phone: 858-249-5985
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.