Understanding maternal health after preeclampsia
Official title: Multi-Omics for Maternal Health After Preeclampsia
Run by University of California, San Diego · NCT06340152 · Data updated 2026-11-12
This study is trying to find out how to help new moms who had preeclampsia stay healthy and avoid heart problems after giving birth.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 1100 (estimated) |
| Sponsor | University of California, San Diego Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (San Diego, California) |
| Status | Recruiting |
| Started | December 20, 2023 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | April 6, 2025 |
| Trial ID | NCT06340152 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant women aged 18 to 50 years, between 10 to 24 weeks of gestation, with a singleton pregnancy planning to deliver at a study site.
✕Probably not a fit
Patients with multi-fetal gestation, significant fetal anomalies, or those who cannot provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify postpartum women at risk for adverse cardiovascular outcomes following preeclampsia and develop preventative strategies. It will recruit a diverse group of pregnant women, both high- and low-risk for hypertensive disorders, to collect phenotypic, environmental, and multi-omic data. Participants will be enrolled by 24 weeks of gestation and followed for one year postpartum, with data collected through surveys, cardiovascular assessments, and biospecimen analysis. The study will take place at UCSD and VUMC, with options for participants to choose private locations for visits.
Why it matters
Potential benefit: If successful, this study could lead to improved preventative therapies for postpartum women at risk of cardiovascular issues after preeclampsia.
How similar studies have gone: Other studies have shown promise in understanding maternal health post-preeclampsia, but this multi-omics approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women 18 years of age to 50 years of age * 10-24 weeks gestation at time of enrollment * Singleton pregnancy * Planning to deliver at a study site (UCSD or VUMC) Exclusion Criteria: * Inability to give informed consent * Intrauterine fetal demise * Fetal genetic or structural anomaly * Institutionalization for psychiatric disorder, mental deficiency or incarcerated * Active or history of malignancy requiring major surgery or systemic chemotherapy * Multi-fetal gestation or a twin demise at any gestational age * Known maternal or fetal chromosomal anomalies * Patients who plan to keep their placenta after delivery
Where it's running
-
University of California, San Diego
San Diego, California, United States Recruiting
Study contacts
- Principal investigator: Louise Laurent, MD, PhD — UCSD
- Study coordinator: Maya Selvaraj
- Email: momhealthstudy@health.ucsd.edu
- Phone: 858-249-5985
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Preeclampsia Biomarker Test in African Women
This study tests whether measuring the sFlt-1/PlGF ratio using quick clinic tests helps predict which pregnant women in Africa will develop severe preeclampsia.
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This study tests whether ultrasound of the internal jugular vein can show differences in fluid status between preeclamptic pregnant people and those with normal blood pressure during planned cesarean delivery.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.