Heart function during and after pre-eclampsia
SHePREG: Study of Heart function in PRE-Eclampsia during and after PreGnancy
This project looks at how severe pre-eclampsia affects heart function in pregnant women from different racial backgrounds by checking heart health at delivery and up to a year later and linking findings to genetic differences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11258930 on NIH RePORTER |
What this research studies
If you had severe pre-eclampsia, researchers will measure your heart function at the time of delivery and again at 6 and 12 months after birth. They will also collect a genetic sample to look for inherited changes linked to cardiomyopathy. The team will compare results across Non-Hispanic Black, Non-Hispanic White, Hispanic, and South/Southeast Asian women to see whether heart changes or genetic patterns differ by group. Computer analyses will help predict which genetic variants might affect heart health after pregnancy.
Who could benefit from this research
Good fit: Ideal candidates are women who experienced severe pre-eclampsia during pregnancy and can attend visits at delivery and at 6- and 12-months postpartum and provide a genetic sample.
Not a fit: People without a history of pre-eclampsia, those with only mild hypertensive pregnancy issues, or those unable to attend follow-up visits or provide genetic samples are unlikely to benefit directly from participating.
Why it matters
Potential benefit: This work could help identify women at higher risk for lasting heart problems after pre-eclampsia so they can get closer follow-up or earlier treatment.
How similar studies have performed: Previous pilot data from the team show persistent heart dysfunction up to 3 months postpartum and a higher frequency of cardiomyopathy-linked genetic variants, but this larger, racially diverse, year-long follow-up with detailed genetic analysis is relatively new.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Bradley, Elisa Ann — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Bradley, Elisa Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.