Pre-eclampsia risk in pregnancies after oocyte donation
Official title: PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients) - Investigating Matching, Biomarkers and Outcomes.
Run by Copenhagen University Hospital, Hvidovre · NCT07263490 · Data updated 2026-11-12
We will follow pregnant women who used donated eggs and women who used their own eggs to see if pregnancies after oocyte donation lead to a higher risk of pre-eclampsia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 462 (estimated) |
| Sponsor | Copenhagen University Hospital, Hvidovre Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 6 sites (Copenhagen and 5 other locations) |
| Status | Recruiting |
| Started | October 21, 2024 |
| Main results expected | October 31, 2027 |
| Study ends | June 1, 2028 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT07263490 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant women aged over 18 with BMI under 35 who conceived via oocyte donation or via IVF with their own eggs and who meet the study's health eligibility criteria.
✕Probably not a fit
Women who are not pregnant, who conceived naturally, or who have exclusion conditions (for example HIV/hepatitis, essential hypertension, uncontrolled thyroid disease, recent cancer treatment, smoking or substance abuse) are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational cohort study enrolls two groups: pregnancies after oocyte donation and pregnancies after IVF with autologous oocytes. Participants are followed throughout pregnancy with regular blood samples, blood pressure measurements, clinical examinations, and ultrasound scans, and clinical outcomes are recorded after delivery. The study will analyze biomarkers and routine obstetric data to explore pathophysiological mechanisms and differences in pre-eclampsia risk between the cohorts. Data collection is standardized across participating fertility clinics and the university hospital sites.
Why it matters
Potential benefit: If successful, the findings could clarify why oocyte donation pregnancies have higher pre-eclampsia risk and support better monitoring or targeted preventive care for these pregnancies.
How similar studies have gone: Previous observational studies have consistently reported higher pre-eclampsia rates after oocyte donation, but the underlying mechanisms remain incompletely understood.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * BMI \< 35 kg/m2 * Normal wet smear within the past three years * Both nulli- and multiparous * Singletons and multiple gestations Exclusion Criteria: * Age \< 18 years * BMI \> 35 kg/m2 * HIV/ hepatitis * Essential hypertension * Chronic kidney disease * Undiagnosed vaginal bleeding * Uterine malformations * Persisting ovarian cysts * Tumors in hypothalamus, pituitary, thyroid, or adrenal glands. * Previous breast cancer * Known BRCA 1 or 2 gene * Unregulated thyroid disease * Cardiovascular disease * Breast feeding * Present or previous chemotherapy/radiation therapy * Present or previous malignant disease * Smoking * Alcohol/drug abuse
Where it's running
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Copenhagen Fertility Center
Copenhagen, Denmark Recruiting -
Trianglen Fertility Clinic
Hellerup, Denmark Recruiting -
Fertility Clinic, Herlev / Gentofte Hospital
Herlev, Denmark Recruiting -
Sellmer Klinik
København S, Denmark Recruiting -
Fertility Clinic, Rigshospitalet
København Ø, Denmark Recruiting -
Aleris Fertility
Søborg, Denmark Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.