Investigating the role of anti-C1q autoantibodies in pregnancy complications

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between anti-C1q autoantibodies and pre-eclampsia, a common complication during pregnancy. It involves blood sampling from women with physiological pregnancies, those diagnosed with pre-eclampsia, and women with autoimmune conditions. The study seeks to understand how C1q, a key molecule in the complement system, may influence pregnancy outcomes and the development of pre-eclampsia. By analyzing the presence of these autoantibodies, researchers hope to gain insights into their potential role in placental dysfunction and related complications.

Why it matters

Who can join: the full rules

Inclusion Criteria Group 1. Women occurring physiological pregnancies that sign the consent to participate in the study and agree to spontaneously return to the maternal hospital 40 days after delivery.

Group 2. Patients diagnosed for PE (hypertension arisen suddenly after the 20th week of pregnancy with associated proteinuria, greater than or equal to 300 mg/24 hours often corresponding to 30 mg/dL (1+) on a single sample).

Group 3. Women affected by SLE, APS, or autoimmune thyroiditis attending the medically assisted procreation department or the Department of Rheumatology, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia

Exclusion criteria

1. Women aged under 18 years
2. Viral or bacterial blood transmitted infections.
3. Patients whose informed consent cannot be obtained.

Where it's running

• Institute for Maternal and Child Health - IRCCS "Burlo Garofolo"
  Trieste, Italy Recruiting

Study contacts

• Study coordinator: Chiara Agostinis, BSc
• Email: chiara.agostinis@burlo.trieste.it
• Phone: +39.040.5588652

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.