Investigating how specific immune cells contribute to the recurrence of gum disease
The Role of CD4+ Memory T cell Subtypes in Periodontal Disease Recurrence
This study is looking at how certain immune cells in the body might be involved in the return of gum disease, using a special mouse model to see how these cells react to germs and affect gum health over time, which could help us find better ways to treat and prevent gum problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11310401 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CD4+ memory T cells in the recurrence of periodontal disease, a common gum condition. By using a specialized mouse model, the researchers aim to explore how these immune cells respond to microbial antigens and their impact on gum health over time. The study will analyze how repeated episodes of periodontal disease affect the immune response and bone loss in the gums. This approach could lead to better insights into the underlying mechanisms of gum disease recurrence and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced recurrent periodontal disease.
Not a fit: Patients who have not been diagnosed with periodontal disease or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal disease, reducing its recurrence and associated complications.
How similar studies have performed: Previous research has shown that targeting immune responses can lead to significant advancements in managing chronic diseases, suggesting potential success for this approach.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Alvarez Rivas, Carla — State University of New York at Buffalo
- Study coordinator: Alvarez Rivas, Carla
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.