Omega-3s and low-dose aspirin for smokers with stage III periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled trial evaluating whether omega-3 fatty acids (EPA and DHA) plus low-dose aspirin as an adjunct to scaling and root planing can improve periodontal outcomes. Participants are smokers aged 30-50 with stage III periodontitis and at least 20 teeth, assigned to receive either the omega-3/aspirin combination or placebo after SRP, with follow-up at 3 and 6 months. Primary endpoints include changes in probing pocket depth and clinical attachment level; secondary endpoints include inflammatory biomarkers such as IL-1β in gingival crevicular fluid and other clinical parameters. The study measures both clinical and biochemical responses to host-modulation therapy in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \- Male or female smokers aged 30 to 50 years.
* Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification.
* Probing pocket depth (PPD) ≥ 5 mm.
* Clinical attachment loss (CAL) ≥ 5 mm.
* Presence of at least 20 natural teeth.
* Willing and able to provide written informed consent.

Exclusion Criteria:

* \- Systemic diseases affecting periodontal health.
* Pregnancy or lactation.
* Periodontal treatment within the previous 6 months.
* Use of antibiotics or anti-inflammatory drugs within the previous 6 months.
* Allergy or hypersensitivity to omega-3 fatty acids or aspirin.
* Long-term anticoagulant therapy.
* History of gastric ulcer or bleeding disorders.
* Participation in another clinical trial within the previous 3 month

Where it's running

• Faculty of Dental Medicine for Girls, Al-Azhar University
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: naglaa M EL wakeel, professor — Faculty of Dental Medicine for Girls, Al-Azhar University
• Study coordinator: ALAA hesham mah,oud, BDS, MSc Candidate
• Email: alaahesham419@gmail.com
• Phone: +201146816128

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.