Investigating how a specific receptor in mast cells affects gum disease
Role of a novel G protein-coupled mast cell receptor-mediated pathways in periodontal disease
This study is looking at a new receptor in mast cells that might play a role in gum disease, and it's for people who want to understand how this could help improve treatments for their periodontal issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10902664 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a newly identified receptor in mast cells that may contribute to periodontal disease, a chronic inflammatory condition affecting the gums and supporting structures of teeth. The study will explore how this receptor, known as MRGPRX2, influences mast cell activation and recruitment in the context of gum disease. By using humanized mouse models, researchers aim to uncover the mechanisms behind mast cell involvement in periodontal inflammation and bone loss, which could lead to new therapeutic strategies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic periodontitis who may benefit from new treatment approaches targeting mast cell activity.
Not a fit: Patients without periodontal disease or those with other unrelated dental conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that target mast cell activity, potentially improving outcomes for patients with periodontal disease.
How similar studies have performed: While the specific approach of targeting MRGPRX2 in mast cells is novel, similar studies have shown promise in understanding mast cell roles in other inflammatory diseases.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Ali, Hydar — University of Pennsylvania
- Study coordinator: Ali, Hydar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.