Diode laser added to deep cleaning for gum disease.
Official title: Evaluation of the Effect of Adjunctive Diode Laser Therapy in Mechanical Scaling and Root Surface Debridement in Non-Surgical Periodontal Therapy
Run by Tel Aviv University · NCT07446127 · Data updated 2026-11-12
This test will see if adding a 940-nm diode laser to deep cleaning helps adults with periodontal pockets and attachment loss more than deep cleaning alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Tel Aviv University Academic / other |
| Locations | 1 site (Afula, North) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | March 3, 2026 |
| Trial ID | NCT07446127 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults who are systemically healthy, have at least 20 teeth with significant periodontal pockets (≥30% of sites and ≥2 teeth per quadrant with probing depths ≥5 mm) and radiographic bone loss are ideal candidates.
✕Probably not a fit
Smokers, people with systemic diseases affecting the periodontium, those on medications that affect periodontal status, pregnant or lactating women, and patients who had periodontal treatment within the past 12 months are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized split-mouth trial compares standard non-surgical root surface debridement (scaling and root planing) alone to the same treatment with adjunctive 940-nm diode laser therapy, with quadrants in each patient randomly assigned to one of the two approaches. Eligible, systemically healthy adults must have at least 20 teeth, at least five teeth per quadrant, ≥30% of sites involved, and at least two teeth per quadrant with probing depths ≥5 mm and radiographic bone loss. Clinical periodontal outcomes such as probing depth reduction and changes in clinical attachment level will be measured to compare effectiveness between treatments. The trial is conducted at a single center affiliated with Tel Aviv University in Afula, Israel.
Why it matters
Potential benefit: If successful, adding diode laser therapy could produce greater pocket depth reduction and better attachment level preservation than cleaning alone.
How similar studies have gone: Previous studies of adjunctive diode lasers with scaling and root planing have shown mixed results, with some reporting modest additional pocket depth reduction while overall evidence remains inconclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Systemically healthy patients 2. Each patient should have more than 20 teeth remaining, and at least 5 teeth per quadrant 3. Each patient presented ≥ 30% of sites involved 4. At least 2 teeth with a probing depth of ≥ 5 mm in each quadrant, with evident radiographic bone loss. Exclusion Criteria: 1. History of systemic diseases affecting the periodontium 2. Smokers and alcoholic patients 3. Use of medication within the last 6 months, which might affect the periodontal status 4. Pregnant and lactating women 5. Patients who had any periodontal treatment ≤ 12 months before the examination.
Where it's running
-
Dr Younis Mahmoud
Afula, North, Israel Recruiting
Study contacts
- Study coordinator: Mahmoud Dr Younis, DMD
- Email: younisma@hotmail.com
- Phone: +972544934823
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Autologous Tooth Graft vs. Bovine Xenograft for Healing After Lower Wisdom Tooth Extraction
This study tests whether using tooth-derived grafts from the extracted tooth or bovine grafts improves healing of periodontal defects after removing impacted lower wisdom teeth, compared to natural blood clot healing.
-
Dental Loupes vs. Dental Operating Microscope for Non-Surgical Periodontal Treatment
This study tests whether using dental loupes or a dental operating microscope makes non-surgical periodontal cleaning more effective for adults with periodontitis.
-
Thermosensitive Gel With Octenidine as an Adjunct to Standard Periodontal Cleaning
This study tests whether PX-Gel, a thermosensitive hyaluronic acid-octenidine gel, added to scaling and root planing helps healing periodontal pockets in adults with periodontitis.
-
Adjuncts to non-surgical periodontal treatment in smokers and non-smokers with periodontitis
This trial tests whether adding I-PRF, povidone-iodine, or diode laser to standard deep cleaning helps reduce pocket depth and improve gum health in adults with periodontitis, including smokers.
-
Omega-3s and low-dose aspirin for smokers with stage III periodontitis
In adults who smoke and have stage III periodontitis, this study tests whether adding omega-3 fatty acids and a small amount of aspirin to standard cleaning helps improve gum health.
-
Minimally Invasive vs Conventional Non-Surgical Periodontal Therapy in Stage III Periodontitis
This study tests whether a minimally invasive non-surgical approach works as well as the standard cleaning method for people with stage III periodontitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.