Understanding how aging affects bone loss in gum disease
The role of cellular senescence in bone loss and recovery in periodontal disease
This study is looking at how aging cells affect bone loss in people with gum disease, and it aims to find out if a special treatment can help improve bone health for those who haven't had success with other options.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11040235 on NIH RePORTER |
What this research studies
This research investigates the role of cellular senescence, or the aging of cells, in the loss of bone associated with periodontal disease, which is a common cause of tooth loss in adults. The study aims to identify mechanisms that contribute to age-related bone loss in periodontal disease, particularly focusing on the accumulation of senescent cells. By using a model that mimics periodontal disease in mice, researchers will explore how treatments that target these senescent cells, such as the drug fisetin, can potentially improve bone recovery. This could lead to new therapies for patients who do not respond to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing periodontal disease, particularly those who are older and may be at higher risk for bone loss.
Not a fit: Patients with periodontal disease who are younger and do not exhibit signs of age-related bone loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse bone loss in patients with periodontal disease.
How similar studies have performed: Previous research has shown promise in targeting senescent cells for various age-related conditions, suggesting that this approach may be effective in treating periodontal disease as well.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Kittaka, Mizuho — Augusta University
- Study coordinator: Kittaka, Mizuho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.