Minimally Invasive vs Conventional Non-Surgical Periodontal Therapy in Stage III Periodontitis
Official title: Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients (Randomized Controlled Clinical Trial)
Run by Mansoura University · NCT07671274 · Data updated 2026-11-12
This study tests whether a minimally invasive non-surgical approach works as well as the standard cleaning method for people with stage III periodontitis.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 40 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah, Dakhlia) |
| Status | Recruiting |
| Started | August 5, 2025 |
| Main results expected | August 5, 2026 |
| Study ends | August 5, 2026 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT07671274 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with stage III periodontitis, medically healthy, non-smokers, and with good oral hygiene.
✕Probably not a fit
Patients who are pregnant, have systemic conditions affecting periodontal health, or recently had periodontal treatment or antibiotics may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this early-phase study, 30 adults with stage III periodontitis will be assigned to compare minimally invasive non-surgical therapy (MINST) with conventional non-surgical periodontal therapy (CNST). All participants receive standardized oral hygiene instruction and home care reinforcement. Subgingival biofilm and calculus will be removed using different instrumentation approaches, with MINST employing thinner, delicate piezo-electric tips. Outcomes will focus on clinical measurements of periodontal health to see if MINST can achieve similar or better results than CNST. The study is conducted at Mansoura University’s Faculty of Dentistry in Egypt.
Why it matters
Potential benefit: If successful, MINST could offer a less invasive option with comparable efficacy for improving gum health in stage III periodontitis.
How similar studies have gone: Previous work has explored minimally invasive approaches in periodontal care, with evidence suggesting potential benefits but not definitively established for this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Patients with stage III pericdontitis, according to the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) periodontal classification system . * Medically free patients. * Non-smokers * Patients with good oral hygiene. Exclusion Criteria: * Pregnant or lactating females. * Patients with systemic diseases that might affect periodontal health * previous periodontal treatment within 6 months before baseline examination. * prior antibiotic regimen use within 1 month before baseline examination
Where it's running
-
Mansoura university Faculty of dentistry
Al Mansurah, Dakhlia, Egypt Recruiting
Study contacts
- Study coordinator: fatma saad elsherbini, phd
- Email: elsherbinifatma@mans.edu.eg
- Phone: +201128065677
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.