Clinical trial Recruiting at 1 site Early Phase 1 Interventional Ages 20 to 40

Minimally Invasive vs Conventional Non-Surgical Periodontal Therapy in Stage III Periodontitis

Official title: Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients (Randomized Controlled Clinical Trial)

Run by Mansoura University · NCT07671274 · Data updated 2026-11-12

This study tests whether a minimally invasive non-surgical approach works as well as the standard cleaning method for people with stage III periodontitis.

More Periodontal Disease trials

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Ages20 Years to 40 Years
SexAll
Enrollment30 (estimated)
SponsorMansoura University
Academic / other
Locations1 site (Al Mansurah, Dakhlia)
StatusRecruiting
StartedAugust 5, 2025
Main results expectedAugust 5, 2026
Study endsAugust 5, 2026
Registry record updatedJune 26, 2026
Trial IDNCT07671274 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with stage III periodontitis, medically healthy, non-smokers, and with good oral hygiene.

Probably not a fit

Patients who are pregnant, have systemic conditions affecting periodontal health, or recently had periodontal treatment or antibiotics may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this early-phase study, 30 adults with stage III periodontitis will be assigned to compare minimally invasive non-surgical therapy (MINST) with conventional non-surgical periodontal therapy (CNST). All participants receive standardized oral hygiene instruction and home care reinforcement. Subgingival biofilm and calculus will be removed using different instrumentation approaches, with MINST employing thinner, delicate piezo-electric tips. Outcomes will focus on clinical measurements of periodontal health to see if MINST can achieve similar or better results than CNST. The study is conducted at Mansoura University’s Faculty of Dentistry in Egypt.

Why it matters

Potential benefit: If successful, MINST could offer a less invasive option with comparable efficacy for improving gum health in stage III periodontitis.

How similar studies have gone: Previous work has explored minimally invasive approaches in periodontal care, with evidence suggesting potential benefits but not definitively established for this population.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* • Patients with stage III pericdontitis, according to the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) periodontal classification system .

  * Medically free patients.
  * Non-smokers
  * Patients with good oral hygiene.

Exclusion Criteria:

* Pregnant or lactating females.

  * Patients with systemic diseases that might affect periodontal health
  * previous periodontal treatment within 6 months before baseline examination.
  * prior antibiotic regimen use within 1 month before baseline examination

Where it's running

  • Mansoura university Faculty of dentistry
    Al Mansurah, Dakhlia, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.