OROXID oral solution for treating periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with generalized Stage III, Grade B periodontitis will be assigned to receive either OROXID forte oral solution, OROXID sensitive oral solution, or standard of care as an adjunct to routine mechanical periodontal therapy. The study will monitor clinical periodontal measures (such as pocket depth and attachment levels) and record any adverse effects related to the mouth rinses. Participants must be systemically healthy, have at least 16 natural teeth, and present multiple pockets deeper than 5 mm. The trial aims to collect safety and efficacy data on topical hydrogen peroxide–based oral solutions as an adjunct to mechanical plaque control.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Systemically healthy participants aged 18 years or older.
2. Generalized periodontitis, Stage III, Grade B.
3. Presence of three or more periodontal pockets deeper than 5 mm.
4. At least 16 natural teeth (excluding wisdom teeth).
5. Ability to comply with oral hygiene instructions following the intervention.
6. Signed informed consent form after being fully informed about the study.

Exclusion Criteria:

1. Periodontal treatment within the past six months.
2. Dental procedures (surgery, professional cleaning, scaling and root planing, laser therapy, piezotome) within the past six months.
3. Periodontitis, Stage IV.
4. Use of mouth rinses or oral gels within the past month.
5. Use of antibiotic therapy within the past three months.
6. Ongoing therapy with antihypertensives, antilipemics, antiarrhythmics, or other cardiovascular medications.
7. Systemic diseases such as diabetes, HIV/AIDS, liver diseases, chronic kidney disease, tuberculosis, and autoimmune disorders (e.g., lupus, scleroderma, Crohn's disease).
8. History of cardiovascular diseases, including acute myocardial infarction, angina pectoris, heart failure, atrial fibrillation, atrioventricular block, peripheral artery disease, or stroke.
9. Therapy with immunosuppressive agents.
10. Allergy to any ingredients of the study products.
11. Pregnant or breastfeeding women.

Where it's running

• Klinika Križaj Ljubljana
  Ljubljana, Slovenia Recruiting
• Ustna medicina d.o.o.
  Ljubljana, Slovenia Recruiting

Study contacts

• Principal investigator: Urban Matoh, DMD — Klinika Križaj Ljubljana
• Study coordinator: Dominika Tompa Majcen, MPharm
• Email: dominika@enikam-oxy.com
• Phone: +386 40 530 663

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.