Autologous Tooth Graft vs. Bovine Xenograft for Healing After Lower Wisdom Tooth Extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, randomized, split-mouth trial compares three healing approaches after bilateral lower third molar extraction: autologous tooth graft, bovine xenograft, and natural blood clot healing. The main outcome is the reduction of probing depth on the distal surface of the second molar at six months. Secondary outcomes include postoperative healing parameters and safety measures. The study is conducted at the Complutense University of Madrid with adult participants who need bilateral extractions. It examines whether autologous tooth grafts offer a biocompatible alternative to bovine grafts in promoting periodontal regeneration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years old) of any sex, able to understand and follow study instructions.
* Patients requiring bilateral surgical extraction of impacted lower third molars in horizontal or mesioangular position.
* Presence of both lower second molars.
* Classified as ASA I or ASA II (according to the American Society of Anesthesiologists).
* Willingness to participate voluntarily and sign informed consent.

Exclusion Criteria:

* Age under 18 years.
* ASA physical status III, IV, V, or VI.
* Pregnant or breastfeeding women.
* Immunosuppressed patients.
* Current treatment with NSAIDs, anticoagulants, or acetylsalicylic acid.
* Previous or current treatment with bisphosphonates.
* Presence of oral dysplasia or precancerous lesions.

Where it's running

• Postgrado de especialización en cirugía bucal e implantología, Facultad de Odontología, Universidad Complutense de Madrid
  Madrid, Madrid, Spain Recruiting

Study contacts

• Study coordinator: Miguel Ruiz Rincón, DDS
• Email: migrui02@ucm.es
• Phone: 680276072

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.