Research on how obesity and bariatric surgery affect the body

Surgical-imaging Combined Research on Obesity

This study looks at how obesity affects the body and how bariatric surgery changes things for people who are obese, comparing them to healthy volunteers.

Quick facts

• Study type: Observational
• Enrollment: 200 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: The Affiliated Hospital of Xuzhou Medical University (other)
• Locations: 1 site (Xuzhou, Jiangsu)
• Trial ID: NCT06268262 on ClinicalTrials.gov

What this trial studies

This observational study investigates the systemic changes that occur in the body due to obesity and the alterations that follow bariatric surgery. By integrating MRI imaging with biological and epidemiological data, the research aims to uncover the mechanisms behind obesity and the effects of surgical intervention. The study focuses on individuals who meet specific criteria for obesity and healthy volunteers for comparison. It seeks to provide insights into the relationship between obesity and various health conditions.

Who should consider this trial

Good fit: Ideal candidates include individuals aged 18-65 with a BMI over 28 who are planning to undergo bariatric surgery for the first time.

Not a fit: Patients with secondary obesity due to other medical conditions or those unable to undergo surgery will not benefit from this study.

Why it matters

Potential benefit: If successful, this research could enhance understanding of obesity mechanisms and improve treatment strategies for patients undergoing bariatric surgery.

How similar studies have performed: While there have been studies on obesity and bariatric surgery, this specific approach combining imaging and systemic analysis is relatively novel.

Eligibility criteria

Inclusion Criteria for obesity group:

Meeting the obesity criteria (BMI \> 28); 2) Meeting the indications for bariatric surgery, planning to undergo surgery for the first time; 3) Age between 18-65 years old, no gender restrictions; 4) Right-handed, of Han ethnicity; 5) Informed consent to the study, willing to cooperate with the research, and able to sign an informed consent form.

Inclusion Criteria for the Control Group:

1. Healthy volunteers with a BMI between 18.5-23.9;
2. Age between 18-65 years old, no gender restrictions;
3. Right-handed, of Han ethnicity;
4. Informed consent to the study, willing to cooperate with the research, and able to sign an informed consent form.

Exclusion Criteria for obesity group:

1. Secondary obesity caused by other organic diseases or medication (such as hormone use, etc.);
2. Unable to undergo surgery as planned;
3. Pregnant or breastfeeding;
4. Low cognitive ability and incapable of cooperating with the study;
5. Eating disorders;
6. Alcohol or drug dependence;
7. Meeting the criteria for organic mental disorders, severe mental disorders (schizophrenia, etc.), or other serious mental illnesses requiring clinical intervention;
8. Contraindications for MR scanning (pacemakers, cochlear implants, metal objects in the body, claustrophobia, weight exceeding the machine's load limit, etc.);
9. History of neurological organic diseases (brain tumors, epilepsy, cerebrovascular accidents, severe head trauma, etc.);
10. History of congenital heart disease (myocardial infarction, severe arrhythmias, heart failure, cardiomyopathy, rheumatic heart disease, congenital heart disease, etc.);
11. Severe liver, kidney, lung, digestive dysfunction, endocrine, and blood system diseases;
12. Active infections within the last two weeks (fever, upper respiratory infection, acute gastroenteritis, etc.);
13. Use of drugs affecting the nervous system or psychotropic drugs within the last six months.

Exclusion Criteria for the Control Group:

The same criteria as points 3) to 13) above.

Where this trial is running

Xuzhou, Jiangsu

• Affiliated Hospital of Xuzhou Medical University — Xuzhou, Jiangsu, China (RECRUITING)

Study contacts

• Study coordinator: Kai Liu, Prof.

Conditions: Overweight and Obesity, Obesity, Overweight, MRI, Bariatric surgery, Fatty liver