Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

Choosing AVOID or RESIST to help weight management

Official title: CHOICE to AVOID or RESIST: Evaluating Participants' Choice of Self-regulatory Strategy on Weight Management Outcomes: A Pilot Study.

Run by Cedars-Sinai Medical Center · NCT06521021 · Data updated 2026-11-12

Participants will test whether choosing a self-regulatory strategy (AVOID or RESIST) leads to better adherence to a weight-management program for overweight and obese adults.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment60 (estimated)
SponsorCedars-Sinai Medical Center
Academic / other
Locations1 site (Beverly Hills, California)
StatusRecruiting
StartedJune 1, 2026
Main results expectedJuly 1, 2027
Study endsJuly 1, 2027
Registry record updatedSeptember 22, 2026
Trial IDNCT06521021 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18+ with BMI 25-45 kg/m2, English-reading/writing proficiency, and no contraindications to weight loss interventions.

Probably not a fit

Individuals not seeking to engage with a self-regulatory strategy or those with contraindications to weight-management programs may see no benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares participants who choose a self-regulatory strategy (AVOID or RESIST) with those randomized to a strategy in the parent AVOID-RESIST program, all within the WW digital weight-management platform for 6 months. The goal is to see if active choice improves adherence, retention, and engagement. Adults with BMI 25-45 kg/m2, who speak English and can complete study assessments, will participate; lead site is Cedars-Sinai with collaboration from UC Riverside, Northeastern University, and WW. Participants will be assigned to one of four arms in the randomized group and CHOICE participants will select their preferred strategy to support behavior change per WW recommendations.

Why it matters

Potential benefit: If successful, allowing participants to choose a strategy may improve adherence and weight-management outcomes.

How similar studies have gone: Prior similar approaches have shown mixed results; this design is testing a novel element of active choice within a structured program.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 years or older
* BMI between 25-45 kg/m2
* Read, write, and speak English with acceptable visual acuity

Exclusion Criteria:

* Currently enrolled in weight loss interventions or undergoing bariatric surgery
* Pregnant women
* Individuals for whom weight loss may be contraindicated (e.g., unstable coronary artery disease, end-stage disease, active cancer treatment, uncontrolled insulin-dependent diabetes, portal hypertension, drug/alcohol abuse)
* Individuals who have pacemakers or other electronic medical device implantations
* Individuals with severe cognitive delays or visual/hearing impairment
* Individuals who are unable or unwilling to complete the study assessments / measurements
* Individuals currently subscribed to a meal delivery service who are unwilling to pause their subscription for the duration of the study

Where it's running

  • Cedars-Sinai Medical Center
    Beverly Hills, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.