Comparing Liraglutide and Insulin Glargine for Type 2 Diabetes Management

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This 24-week, open-label, randomized trial evaluates the efficacy and safety of Liraglutide combined with prandial insulin versus insulin glargine combined with prandial insulin in overweight and obese patients with uncontrolled type 2 diabetes. The study aims to address the challenges of insulin therapy, including weight gain and hypoglycemia, by exploring the potential benefits of adding GLP-1 receptor agonists to insulin regimens. Participants will be monitored for changes in glucose control and weight over the trial period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: 18 - 75 years old.
* BMI must be greater than 24 and less than 45 kg/m2
* Patients with type 2 diabetes who met the World Health Organization (who) diagnostic criteria (1999).
* Newly diagnosed type 2 diabetic patients with HbA1c ≥ 9.0%；or patients with uncontrolled type 2 diabetes (HbA1c ≥ 7.5% ) who have received at least two types of oral hypoglycemic drugs (the dose of each drug needs to reach the second largest dose or more), or only insulin (excluding basal-bolus insulin therapy), or insulin with oral hypoglycemic drugs.
* Signed informed consent.

Exclusion Criteria:

* History of pancreatic disease,
* History of medullary thyroid carcinoma
* Lipase level \> 3 times above normal,
* Creatinine clearance ≤ 30 mL/min/1.73m2,
* Evidence in the last 6 months of significant heart disease or stroke, including myocardial infarction, unstable angina, coronary bypass and/or percutaneous transluminal coronary angioplasty, congestive heart failure (New York Heart Association Functional Classification III-IV), or severe ischemic heart disease.
* Preparation for pregnancy or having been in pregnancy
* Researchers believe that there are any factors that affect assessing subjects' participation in trial.
* Patients unable to cooperate in clinical trials

Where it's running

• The first afilliated hospital of Xiamen university
  Xiamen, Fujian, China Recruiting

Study contacts

• Principal investigator: Xuejun Li, MD — The first afilliated hospital of Xiamen university
• Study coordinator: Changqin Liu, MD
• Email: liuchangqin@xmu.edu.cn
• Phone: +86-133-7698-6106

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.