Effects of dietary changes on food choices and brain function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates how dietary interventions that alter the gut microbiome can influence food decision-making in overweight and obese adults. A total of 90 participants will be randomly assigned to receive either a pre-biotic dietary intervention, a behavioral lifestyle intervention, or a control condition over 26 weeks. The study will utilize functional and structural MRI, cognitive testing, and microbiota analysis through stool samples to assess changes in brain function and gut health. The goal is to understand the mechanisms behind how diet impacts food choices and overall health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI \>= 25 kg/m2 or WHR \>= 0.9/0.85 (m/d, f)
* no MRI contra-indication
* written informed consent

Exclusion Criteria:

* athletes
* occurrence of a clinically relevant psychiatric disease in the last 12 months, e.g. depression, substance abuse, eating disorders, schizophrenia
* any chronic inflammatory or malignant disease
* type 1 diabetes
* previous bariatric/gastric surgery
* pregnancy or breastfeeding woman

Where it's running

• Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences
  Leipzig, Germany Recruiting

Study contacts

• Principal investigator: Veronica Witte, PhD — Cognitive Neurology, University Medical Center Leipzig
• Study coordinator: Meghedi Vartanian, MSc
• Email: mi-food@cbs.mpg.de
• Phone: +49(0)341/9940-951

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.