Condition

Hypoxia clinical trials and research

• 29Clinical trials
• 204NIH research projects
• 12Countries

Newest Hypoxia clinical trials

All recruiting trials (29)

• How the body responds to exercise with low oxygen in healthy adults

  Researchers test how healthy men and women respond to different exercise types while breathing air with varying oxygen levels.

  Recruiting University Hospital, Grenoble · La Tronche · NCT07671638

• How acute low-oxygen levels affect the right side of the heart in asthma

  This study tests how short-term exposure to simulated high-altitude oxygen levels affects right heart function in adults with asthma.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07431580

• How short-term low oxygen exposure affects the right side of the heart in healthy adults

  We test whether short-term reduced oxygen (simulated 2,500 m and 4,000 m) changes right ventricular function in healthy adults at rest and during light exercise.

  Recruiting University of Zurich · Zurich, Canton of Zurich and 1 other locations · NCT07431567

• Right-heart response to short-term low oxygen in people with past HAPE

  This trial tests whether brief exposure to simulated high altitude (low oxygen) changes right-heart function in adults who previously had high-altitude pulmonary edema (HAPE).

  Recruiting University of Zurich · Zurich · NCT07431554

• Supraglottic oxygen through a thin nasal tube during deep-sedation bronchoscopy

  This trial tests whether inserting a thin, wired endotracheal tube through the nose to deliver oxygen above the vocal cords helps prevent low oxygen levels in adults undergoing deep-sedation fiberoptic bronchoscopy.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT07389083

• High-flow nasal oxygen to prevent low oxygen during sedated endoscopy in people with high-risk sleep apnea

  This will test whether using high‑flow nasal oxygen instead of a regular nasal cannula prevents low oxygen levels during propofol‑sedated gastroscopy or colonoscopy in adults with high‑risk obstructive sleep apnea (STOP‑Bang ≥5).

  Recruiting at 3 sites Zhejiang University · Hangzhou, Zhejiang and 2 other locations · NCT07307560

• Suctioning the breathing tube versus skipping suctioning when waking from general anesthesia

  This tests whether skipping suctioning of the breathing tube right before removal is as safe for adults (18–90) having elective surgery under general anesthesia.

  Recruiting Mahidol University · Samut Sakhon · NCT07287293

• Breathing muscle training plus dietary nitrate to improve exercise at simulated moderate altitude

  This project tests whether breathing muscle training and beetroot-derived nitrate help healthy, active adults exercise better under simulated moderate-altitude (low-oxygen) conditions.

  Recruiting Embry-Riddle Aeronautical University · Daytona Beach, Florida · NCT07216755

• Nasopharyngeal airway plus high-flow nasal oxygen during painless gastroscopy for people with obesity

  This will test whether using a nasopharyngeal airway together with high-flow nasal oxygen keeps oxygen levels safer for adults with obesity during sedated (painless) gastroscopy.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing · NCT06966934

• Effects of low oxygen levels on kidney function in healthy individuals and diabetes patients

  This study is testing how low oxygen levels affect kidney function in healthy people and those with diabetes to see if there are different risks for kidney health.

  Recruiting Poitiers University Hospital · Poitiers · NCT06846034

• Using a new airway device to reduce low oxygen levels during endoscopy in obese patients

  This study tests if a new airway device can help obese patients keep their oxygen levels up during gastrointestinal endoscopy compared to using a regular nasal cannula.

  Recruiting at 3 sites Zhejiang University · Hangzhou, Zhejiang and 2 other locations · NCT06796764

• Using electrical stimulation at acupoints to reduce respiratory issues after anesthesia

  This study is testing if electrical stimulation at certain points on the body can help people recover better from anesthesia by improving their breathing and preventing problems.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu and 1 other locations · NCT06772961

• Comparing High Flow Nasal Oxygen and Nasal Cannula for Burn Patients Under Sedation

  This study is testing whether high flow nasal oxygen can help burn patients breathe better during surgery compared to standard nasal oxygen.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT06756906

• Effects of High-Frequency Oscillatory Ventilation in ICU Patients

  This study is testing whether a new breathing treatment called Continuous High-Frequency Oscillatory Ventilation can improve lung function and comfort for awake ICU patients with collapsed lungs.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT06702813

• Effects of suctioning on pain and stress in intubated ICU patients

  This study is testing if suctioning the breathing tube in ICU patients causes more pain and stress compared to not suctioning.

  Recruiting Loma Linda University · Loma Linda, California · NCT06692400

• Effects of intravenous iron on performance at high altitude

  This study is testing whether getting intravenous iron can help people perform better and breathe easier when exercising at high altitudes compared to a placebo.

  Recruiting Phase 4 United States Army Research Institute of Environmental Medicine · Natick, Massachusetts · NCT06686693

• Examining how aging and menopause affect blood vessel responses to low oxygen levels

  This study is testing how aging and menopause affect blood vessel responses to low oxygen levels in women by trying different medications to see how they help.

  Recruiting Early Phase 1 University of Missouri-Columbia · Columbia, Missouri · NCT06417177

• Effects of exercise in low oxygen on bone health and metabolism in premenopausal women

  This study tests if exercising in low oxygen can improve bone health and metabolism in premenopausal women.

  Recruiting University School of Physical Education, Krakow, Poland · Krakow and 1 other locations · NCT06226168

• Testing pulse oximeter accuracy during low oxygen levels

  This study tests how accurately pulse oximeters measure blood oxygen levels in healthy adults when their oxygen levels drop to different low points.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06142019

• Imaging hypoxia in head and neck cancer for personalized treatment

  This study is testing a new way to use MRI scans to find low-oxygen areas in head and neck cancer patients to help create personalized treatment plans that could improve their response to therapy.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06108089

• COMBO endoscopy oropharyngeal airway for safer propofol‑sedated gastrointestinal endoscopy

  This trial will test whether the COMBO Endoscopy Oropharyngeal Airway reduces low-oxygen episodes in adults having propofol‑sedated gastroscopy or colonoscopy compared with a regular nasal cannula.

  Recruiting at 10 sites RenJi Hospital · Nanjing, Jiangsu and 9 other locations · NCT06081647

• Monitoring brain oxygen levels in newborns on mechanical ventilation

  This study is testing if using a special brain oxygen monitor can help newborns on breathing machines have better health and brain development compared to standard care alone.

  Recruiting Phase 3 Copenhagen Trial Unit, Center for Clinical Intervention Research · Madrid · NCT05907317

• Using High-flow Nasal Oxygen during Intubation in Critically Ill Patients

  This study is testing if using High Flow Nasal Oxygen during intubation can help critically ill patients breathe better and avoid problems compared to standard methods.

  Recruiting Region Stockholm · Stockholm, Stockholm County · NCT05883137

• Comparing high flow nasal cannula to facial masks for chest trauma patients

  This study is testing if high flow nasal cannulas can help chest trauma patients breathe better and avoid needing a breathing tube compared to regular facial masks.

  Recruiting at 2 sites National Taiwan University Hospital · Taipei, Taipei and 1 other locations · NCT05828030

• Point-of-care ultrasound to help diagnose sudden shortness of breath

  This will test whether quick bedside ultrasound used by emergency doctors helps identify the cause of sudden shortness of breath in adults with low oxygen or fast breathing.

  Recruiting at 2 sites Region Skane · Helsingborg, Skåne County and 1 other locations · NCT05782478

• Adaptive radiotherapy using FMISO for head and neck cancer

  This study is testing if using special imaging to find hard-to-treat areas in head and neck cancer can help doctors give higher doses of radiation where it's needed most, along with chemotherapy, to improve patient outcomes.

  Recruiting at 3 sites University Hospital Olomouc · Brno and 2 other locations · NCT05348486

• Going to high altitude with anxiety and depressive symptoms

  This trial will test whether a short, controlled exposure to low oxygen like that at high altitude makes people with anxiety and depressive symptoms feel more anxious or negative and changes certain blood chemical markers.

  Recruiting Universitaet Innsbruck · Innsbruck, Tyrol · NCT05323864

• Short mild low-oxygen sessions to support brain blood-vessel health in older adults

  We will test whether brief, controlled sessions of mild low-oxygen exposure, alone or combined with rehabilitative exercise, can improve brain blood-vessel function in inactive people aged 60 to 80.

  Recruiting University Hospital, Grenoble · La Tronche, Auvergne-Rhône-Alpes · NCT05048680

• Monitoring nocturnal oxygen levels in older patients after hip surgery

  This study is testing if monitoring oxygen levels at night can help understand and possibly prevent confusion in older patients after hip surgery.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT04007432

NIH-funded research (newest 40 of 204)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using MRI to measure brain oxygen levels as an early sign of small vessel disease in the brain

  This study is looking at how measuring oxygen levels in the brain with MRI can help spot early signs of small vessel disease, which is linked to memory problems and dementia, especially Alzheimer's, so if you're at risk due to age or high blood pressure, you might be able to participate in MRI scans to learn more about

  NIH research Washington University · Saint Louis, United States · NIH-9960958

• HIF-driven ways to repair damaged lungs in IPF

  A doctor-researcher is testing how low-oxygen signals (HIF) could help restore healthy lung tissue in people with IPF.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11577275

• Neonatal Brain Injury Protection with New Purine Compounds

  A new medication approach using purine derivatives is being studied to protect newborn brains from injury caused by limited blood flow and oxygen during birth.

  NIH research Women and Infants Hospital-Rhode Island · Providence, United States · NIH-11541249

• Aldo-keto reductase (AKR) helps brain BH4 levels after injury

  This grant tests whether brain AKR enzymes can boost BH4 levels and support better brain function after hypoxia-ischemia-related injury.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11447154

• Dual-hypoxia and proliferation PET biomarker for recurrent glioblastoma

  A study using a special PET imaging approach to map oxygen-poor areas and cell growth in recurrent brain tumors to guide treatment decisions.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11445726

• How low oxygen and genetic tweaks may repair mitochondrial problems linked to Alzheimer’s and other disorders

  A Johns Hopkins-style? (Note: institution specified later) patient-facing overview: researchers will study tiny cell power stations in mitochondria to see if low-oxygen conditions and specific genetic changes can fix problems associated with Alzheimer's disease and related dementias.

  NIH research Brandeis University · Waltham, United States · NIH-11440919

• How combined low oxygen conditions worsen heart and blood vessel disease

  This project looks at how a mix of chronic and intermittent low oxygen levels harms the heart and metabolism in people with lung disease-related conditions, using mice to uncover clues that could help patients in the future.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11434926

• DNA Repair in Placental Cells Under Low Oxygen

  A funded project at UC San Diego will study how DNA repair problems in the placenta’s early cells contribute to genomic instability under low-oxygen conditions seen in pregnancy complications.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11433344

• Parabrachial Nucleus Cells and Breathing in Hypoxia, Hypercarbia, and Opioids

  Aims to understand how specific brain cells control breathing and waking during low oxygen or high carbon dioxide, and how opioids affect these processes, with the goal of safer treatments.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11415638

• Leptin, intermittent hypoxia, and carotid body signals in obesity-related sleep apnea

  A study at GWU explores how obesity and sleep apnea interact through leptin and carotid body signals to influence blood pressure.

  NIH research George Washington University · Washington, United States · NIH-11413697

• Regulation of EBV Latency and Tumor Growth by Oxygen Levels

  Researchers are studying how low-oxygen conditions help Epstein-Barr Virus–related cancers survive and grow, with the goal of finding new ways to prevent or treat these cancers.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11413554

• Skin cancer caused by the MCPyV virus: how low oxygen may drive Merkel cell carcinoma

  Researchers are studying how low-oxygen conditions in the skin interact with a virus linked to Merkel cell carcinoma to find new ways to prevent and treat this aggressive skin cancer.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11413544

• KSHV-driven tumor formation: how low-oxygen conditions push stem cells toward Kaposi’s sarcoma

  This project explores how low oxygen in tumors helps the Kaposi’s sarcoma virus hijack stem cells to form cancerous blood vessel–rich growths.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11413534

• KSHV virus behavior in low-oxygen conditions

  This research will study how the Kaposi’s sarcoma–associated herpesvirus (KSHV) and infected cells behave and replicate when oxygen levels are very low, which is common in certain cancers.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11413529

• Transcription and Replication of Cancer-Causing Viruses in Low Oxygen

  This grant explores how cancer-causing viruses behave and copy themselves when oxygen is scarce, aiming to understand their role in human cancers.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11413504

• Hypoxia and metabolism as targets to improve immunotherapy in head and neck cancer

  This grant tests new combinations of metabolic drugs with immunotherapy to help people with head and neck cancer respond better to treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11404946

• Optimizing caffeine therapy to protect kidneys and brain in preterm babies

  A randomized study tests whether giving caffeine to very premature babies with kidney and brain hypoxia can reduce kidney injury and improve early brain and kidney outcomes.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11400275

• How low oxygen in tumors makes radiation less effective in esophageal and lung cancers

  This grant explores how low oxygen in tumors may help cancer cells resist radiation therapy, by studying a key cell-death pathway called ferroptosis and related genes.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11395548

• Iron overload and low oxygen in pregnancy with beta-thalassemia

  A patient-friendly look at how excess iron and low oxygen during pregnancy could affect mothers and babies in beta-thalassemia.

  NIH research University of Florida · Gainesville, United States · NIH-11392553

• FGF signaling and vascular remodeling in lung hypertension

  A doctor-scientist at Washington University is studying how fibroblast growth factor (FGF) signaling affects pulmonary hypertension and exploring new potential therapies.

  NIH research Washington University · Saint Louis, United States · NIH-11392512

• Hypoxia-linked NUDT21 and 3'UTR changes drive fibrosis in systemic sclerosis

  A patient-facing study exploring how a gene called NUDT21 and changes in RNA endings may cause skin and lung fibrosis in systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11391972

• Hypoxia-inducible factors and neutrophil diversity in blood clotting in myeloproliferative neoplasms

  A physician-scientist is training over five years to uncover how low-oxygen signals and diverse neutrophils drive dangerous clots in people with myeloproliferative neoplasms, with the goal of finding new treatment targets.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11380793

• Hypoxia and centrosome instability in prostate cancer progression

  A patient-focused look at how low oxygen in prostate tumors may cause cell division errors that drive cancer to become more aggressive.

  NIH research University of Arizona · Tucson, United States · NIH-11374732

• Overcoming immune evasion in chordoma using immune-boosting drugs

  Researchers are testing drugs that block the immune-suppressing effects of adenosine to help the body's immune system fight chordoma tumors in adults.

  NIH research New York University School of Medicine · New York, United States · NIH-11374342

• Sleep, nighttime oxygen, and risk of falls and fractures in older adults

  This study looks at how nocturnal low oxygen during sleep relates to falls and bone fractures in men and women aged 50 and older.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11372814

• How NDRG proteins help cells cope with low oxygen

  This project looks at whether NDRG proteins protect cells from damage when oxygen levels fall, which could matter for people with stroke, acute kidney injury, or sickle cell crises.

  NIH research University of Maryland Baltimore County · Baltimore, United States · NIH-11371409

• Effects of chronic low oxygen and AMPK on placental blood flow and fetal growth

  This grant studies how long-term low oxygen and a cellular energy sensor called AMPK affect uteroplacental blood flow, placental metabolism, and fetal growth in pregnancies at high altitude and in other settings.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11369842

• Hypoxia-mimicking therapy to help recovery in inflammatory demyelinating disease

  Aims to see if drugs that mimic low-oxygen signals can speed recovery and reduce disability in conditions like multiple sclerosis by strengthening blood vessels and helping immune cells leave the brain.

  NIH research San Diego Biomedical Research Institute · San Diego, United States · NIH-11352666

• Fetal heart disease and placental blood flow in pregnancy

  A mother-and-child focused project to understand how placental blood flow in pregnancies with fetal heart disease affects the baby’s brain development.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11352386

• REM sleep disruption and memory: how sleep fragmentation and intermittent hypoxia affect memory in sleep apnea

  This grant tests how interruptions in REM sleep from sleep apnea affect memory and brain activity in adults with obstructive sleep apnea.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11345200

• A MRI-based method to track tumor oxygen levels during radiation therapy

  Researchers are testing MRI-based ways to monitor oxygen in tumors during radiation treatment to tailor doses and improve outcomes for cancer patients.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11344793

• Effects of chronic low oxygen on brain blood flow control in newborns

  A study in newborns and animal models will explore how chronic low oxygen affects the brain’s ability to keep blood flow steady, which is crucial for preventing brain injuries.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-11341894

• How a gut oxygen sensor boosts natural GLP-1 and controls blood sugar

  Looks at whether an oxygen-sensing protein in the gut helps meals trigger GLP-1 release to improve blood sugar control for people with type 2 diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11333263

• Understanding how living at high altitudes changes the body and what it means for heart and brain health

  This NIH grant studies how living in low-oxygen conditions affects breathing, blood flow, and heart health by using wild deer mice to uncover natural biological tricks that help cope with hypoxia.

  NIH research University of Denver (Colorado Seminary) · Denver, United States · NIH-11332588

• Hypoxia, TB, and T cell dysfunction in HIV-related risk settings

  This grant studies how low-oxygen conditions in tuberculosis-affected lungs affect T cells and may lead to weaker immunity in people with AIDS-related risk.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11331249

• Hypoxia-activated probiotic agents to attack breast cancer

  A new probiotic-based approach is being developed to directly target and kill breast cancer cells in the low-oxygen areas of tumors.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11330490

• Hypoxia's role in vein changes after kidney-disease-related dialysis grafts

  This project looks at how low oxygen levels affect vein changes that can block arteriovenous fistulas used for hemodialysis.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11330335

• Role of tumor cell hypoxia pathways in blocking immune attack against cancer

  A doctor-scientist is studying how low-oxygen signals inside tumor cells help tumors hide from the immune system and resist immunotherapy.

  NIH research University of Chicago · Chicago, United States · NIH-11330249

• High-oxygen eye treatment for mustard gas–related eye injuries

  A high-oxygen topical eye emulsion aimed at people with eye injury from mustard gas exposure.

  NIH research Schepens Eye Research Institute · Boston, United States · NIH-11328911

• Adaptive resistance to AR inhibitors in low-oxygen environments linked to GPT1 metabolism

  This grant looks at why prostate cancer becomes resistant to AR-targeting therapies when oxygen is scarce, by studying the GPT1 enzyme.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11325371

Related topics

Quick answers

How many Hypoxia clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in China (7 trials), United States (6 trials), France (4 trials), Switzerland (3 trials), Sweden (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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