Hypoxia, TB, and T cell dysfunction in HIV-related risk settings

Who could benefit from this research

What this research studies

In people with HIV/AIDS risk, latent tuberculosis can become active; this project uses a mouse model to explore how metabolic stress in the lungs, especially low oxygen in granulomas, changes CD4 and CD8 T cell function. The researchers aim to identify why immune defenses fail to contain TB and how hypoxia impacts T cell responses during infection. By comparing T cells from mice with severe disease to those from milder cases, the study seeks to uncover protective mechanisms that could inform future therapies or vaccines. The work focuses on the interaction between M. tuberculosis, metabolism, and T cell immunity in the lung environment.

Why it matters

Where this research is happening

• Univ of Massachusetts Med Sch Worcester
  Worcester, United States Active

Researchers

• Principal investigator: Behar, Samuel M — Univ of Massachusetts Med Sch Worcester
• Study coordinator: Behar, Samuel M

Related research

Other NIH-funded projects on the same topics.

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  NIH research Washington University · Saint Louis, United States · NIH-9960958

• Coronary disease and immune activation in people with HIV and tuberculosis coinfection

  This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.

  NIH research Emory University · Atlanta, United States · NIH-11618831

• Pulmonary rehabilitation to reduce breathing problems after tuberculosis

  A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11607184

• Pulmonary rehab to reduce breathing troubles after TB

  A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11607183

• Air pollution and tuberculosis spread in Kampala, Uganda

  This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11579144

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.