Hypoxia's role in vein changes after kidney-disease-related dialysis grafts
Official title: The role of hypoxia in venous neointimal hyperplasia in hemodialysis grafts
Funded at Mayo Clinic Rochester · NIH-11330335 · Data updated 2026-11-12
This project looks at how low oxygen levels affect vein changes that can block arteriovenous fistulas used for hemodialysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | February 1, 2010 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $710,490 |
| NIH project number | 5R01HL098967-16 |
| Project ID | NIH-11330335 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with end-stage kidney disease who are getting or planning to get an arteriovenous fistula for hemodialysis.
✕Less likely to help
Patients not undergoing fistula-related dialysis or those not considered for autologous cell therapies may not benefit.
What this research studies
If you rely on a fistula for dialysis, this research examines how reduced oxygen in vein tissue influences the thickening and scarring that can block the fistula. Researchers studied autologous fat-derived stem cells placed near the new fistula to see if they help the vein stay open longer. The work uses both human data and animal studies to understand inflammation and aging effects on vein health. Findings could guide future therapies to keep fistulas functioning and reduce complications for people with kidney failure.
Why it matters
Potential benefit: If successful, the work could lead to better methods to keep dialysis fistulas open longer and reduce procedures.
How similar studies have gone: Previous small trials suggest stem cells may influence vein health, but results vary and require confirmation.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Misra, Sanjay — Mayo Clinic Rochester
- Study coordinator: Misra, Sanjay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.