Effects of chronic low oxygen on brain blood flow control in newborns
Official title: Effects of chronic hypoxia on cerebral blood flow autoregulation in the newborn.
Funded at Loma Linda University · NIH-11341894 · Data updated 2026-11-12
A study in newborns and animal models will explore how chronic low oxygen affects the brain’s ability to keep blood flow steady, which is crucial for preventing brain injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | June 15, 2026 |
| Project end | February 28, 2030 |
| Funding year | 2026 |
| Award (this year) | $776,881 |
| NIH project number | 1R01HL185877-01 |
| Project ID | NIH-11341894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Newborns at risk of perinatal brain injury or with a history suggestive of impaired cerebral autoregulation; relevant human samples or data may be used.
✕Less likely to help
Healthy term infants or cases where no impairment of cerebral autoregulation is present may not benefit from this research.
What this research studies
This project looks at how the newborn brain maintains stable blood flow when blood pressure changes, focusing on the role of specific channels and an oxygen-stress molecule. Researchers will use newborn lambs and other models to examine how TrpC6 and Cav1.2 channels control blood vessel constriction in the brain. They will also investigate how chronic perinatal hypoxia and the microRNA miR210 might disrupt this control via epigenetic changes and increased reactive oxygen species. The aim is to map how impaired cerebral autoregulation contributes to injuries like IVH and PVL and to identify potential molecular targets for intervention.
Why it matters
Potential benefit: If successful, the findings could lead to new approaches to protect newborn brains from injury due to unstable blood flow.
How similar studies have gone: Early work indicates TrpC6 and Cav1.2 channels play a role in cerebral vascular regulation, with novel insights expected in the perinatal context.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Blood, Arlin B — Loma Linda University
- Study coordinator: Blood, Arlin B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.