Neonatal Brain Injury Protection with New Purine Compounds

Who could benefit from this research

What this research studies

This project focuses on babies who suffer hypoxia-ischemia around birth, a condition that can lead to long-term brain damage. Researchers will test a new family of purine-based molecules that act on specific brain cell pathways to stabilize mitochondria and reduce inflammation after injury. The work builds on animal data showing cognitive and neural benefits, and aims to translate those findings to newborns using established neonatal injury models. The study will examine how these compounds influence the blood-brain barrier, inflammation, and neuronal survival in the developing brain.

Why it matters

Where this research is happening

• Women and Infants Hospital-Rhode Island
  Providence, United States Active

Researchers

• Principal investigator: Chen, Xiaodi Felix — Women and Infants Hospital-Rhode Island
• Study coordinator: Chen, Xiaodi Felix

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.