How acute low-oxygen levels affect the right side of the heart in asthma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with asthma will be exposed to normobaric hypoxia simulating altitudes of near sea level, 2,500 m, and 4,000 m, both at rest and during light cycling. The trial uses a randomized, double-blind, cross-over design so each participant experiences all conditions in random order. Right ventricular function will be measured with speckle-tracking echocardiography, along with heart rate, blood pressure, oxygen saturation, and symptom reporting. The study aims to understand how acute hypoxia influences right heart performance and related physiologic responses in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed informed consent
* Diagnosed and well controlled asthma bronchiale
* 18-80 years (age group young: 18-39.99 years / age group older: 40-80 years)
* All sex and genders
* Living \<800m and without altitude exposure \> 2500 m and \> 24h within the last three weeks

Exclusion Criteria:

* \<18, \>80 years old
* Any other diagnosed cardiopulmonary condition including past HAPE
* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)
* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders
* Participants permanently living \>800m and altitude exposure \> 2500 m and \>24h within the last three weeks
* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy
* Lactating women
* Participation in other study with active treatment

Where it's running

• Consultant Clinic of Pulmonology, University Hospital of Zurich
  Zurich, Canton of Zurich, Switzerland Recruiting

Study contacts

• Principal investigator: Mona Lichtblau — University of Zurich
• Study coordinator: Mona Lichtblau, PD Dr. med.
• Email: mona.lichtblau@usz.ch
• Phone: +41 442552220

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.