Nasopharyngeal airway plus high-flow nasal oxygen during painless gastroscopy for people with obesity

The Application of Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Patients With Obesity

This will test whether using a nasopharyngeal airway together with high-flow nasal oxygen keeps oxygen levels safer for adults with obesity during sedated (painless) gastroscopy.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 364 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Nanjing First Hospital, Nanjing Medical University (other)
• Locations: 1 site (Nanjing)
• Trial ID: NCT06966934 on ClinicalTrials.gov

What this trial studies

This interventional study enrolls adults with BMI over 28 who are scheduled for sedated (painless) gastroscopy and are ASA physical status I–III. Participants receive a nasopharyngeal airway combined with high-flow nasal oxygen during the procedure, and clinicians monitor oxygen saturation and respiratory events. The main goal is to reduce the incidence of hypoxia and related airway complications during sedated endoscopy in obese patients. The trial is conducted at Nanjing First Hospital as a single-center protocol with periprocedural monitoring and follow-up.

Who should consider this trial

Good fit: Adults older than 18 years with BMI >28 kg/m², ASA I–III, who are scheduled for painless (sedated) gastroscopy and can give informed consent.

Not a fit: Patients with acute upper respiratory infection, severe cardiorespiratory disease, gastrointestinal obstruction, allergy to anesthetic agents, severe hepatic or renal failure, or those who refuse sedation are unlikely to benefit from this intervention.

Why it matters

Potential benefit: If successful, the approach could reduce low-oxygen events and make sedated gastroscopy safer and more comfortable for obese patients.

How similar studies have performed: High-flow nasal oxygen alone has shown benefits in reducing hypoxia during sedated endoscopy in prior studies, while the specific combination with a nasopharyngeal airway is less well studied.

Eligibility criteria

Inclusion Criteria:

1. Patients undergoing painless gastroscopy;
2. Patients with an age greater than 18 years old;
3. American Society of Anesthesiologists (ASA) physical status classification from Grade I to Grade III;
4. Body Mass Index (BMI) greater than 28 kg/m²

Exclusion Criteria:

1. Patients with contraindications to endoscopic procedures or those who refuse sedation/anesthesia;
2. Patients allergic to propofol, eggs, soybeans, milk, etc.;
3. Patients with gastrointestinal tract obstruction and gastric emptying disorders;
4. Patients with acute pharyngitis, tonsillitis, and upper respiratory tract infections;
5. Patients in the acute exacerbation stage of respiratory diseases such as asthma, bronchitis, and chronic obstructive pulmonary disease (COPD);
6. Patients with acute arrhythmia and those with severe heart diseases (congenital diseases, valvular diseases);
7. Patients with severe hepatic and renal insufficiency who require alternative treatment;
8. Patients with severe mental disorders who need medications to control their symptoms;
9. Patients with moderate or above anemia, abnormal coagulation function, and hematological diseases;
10. Patients with nasal cavity lesions leading to severe nasal congestion;
11. Pregnant and lactating patients.

Where this trial is running

Nanjing

• Nanjing First Hospital — Nanjing, China (RECRUITING)

Study contacts

• Study coordinator: Jing Hu, Master

Conditions: Hypoxia, Obesity, Gastrostomy, Obese patients, sedative gastroscopy, high-flow nasal oxygen therapy