Hypoxia and centrosome instability in prostate cancer progression
Official title: Hypoxia-mediated centrosome instability as a driver of prostate cancer progression
Funded at University of Arizona · NIH-11374732 · Data updated 2026-11-12
A patient-focused look at how low oxygen in prostate tumors may cause cell division errors that drive cancer to become more aggressive.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $588,677 |
| NIH project number | 1R01CA307224-01A1 |
| Project ID | NIH-11374732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with prostate cancer, especially those at risk of progression from localized to metastatic disease, could benefit from future translational applications arising from this work.
✕Less likely to help
Patients without aggressive disease or those not participating in future translational studies may not directly benefit.
What this research studies
This project explores how low oxygen levels inside prostate tumors (hypoxia) may cause errors in how cells divide, leading to chromosomal instability and cancer progression. By studying how centrosomes change under hypoxic conditions, researchers hope to uncover mechanisms that push localized prostate cancer toward metastatic disease. The work combines cell culture models and cancer biology to connect oxygen availability with changes in cell division and tumor behavior. If successful, these findings could point to new ways to predict relapse and potentially guide targeted therapies in prostate cancer patients.
Why it matters
Potential benefit: Better understanding of why some prostate cancers become more aggressive could lead to earlier relapse prediction and novel treatment approaches.
How similar studies have gone: Prior work suggests centrosome dynamics and hypoxia influence cancer progression, supporting the potential effectiveness of this line of research.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Rogers, Gregory Charles — University of Arizona
- Study coordinator: Rogers, Gregory Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.