Effects of chronic low oxygen and AMPK on placental blood flow and fetal growth
Official title: Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growth
Funded at University of Colorado Denver · NIH-11369842 · Data updated 2026-11-12
This grant studies how long-term low oxygen and a cellular energy sensor called AMPK affect uteroplacental blood flow, placental metabolism, and fetal growth in pregnancies at high altitude and in other settings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2016 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $664,232 |
| NIH project number | 5R01HD088590-09 |
| Project ID | NIH-11369842 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals, including those at high altitude or with conditions affecting uteroplacental blood flow, as well as appropriate gestational age groups.
✕Less likely to help
Pregnant people without altered uteroplacental blood flow or those not at risk for FGR may not directly benefit.
What this research studies
If you are pregnant, this research looks at why some pregnancies have restricted growth when oxygen is limited. Scientists will study how low oxygen and AMPK activity influence blood flow to the uterus and how the placenta processes nutrients and energy. The work will involve human and sheep studies to understand placental signaling and metabolism under chronic hypoxia. Findings could reveal new ways to support healthy fetal growth in pregnancies challenged by low oxygen. The project builds on prior data showing differences in uterine blood flow and placental metabolism in high-altitude pregnancies.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to prevent fetal growth restriction in pregnancies exposed to low oxygen.
How similar studies have gone: Previous work suggests AMPK is involved in placental blood flow and metabolism; this study extends findings with human and animal models.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Julian, Colleen Glyde — University of Colorado Denver
- Study coordinator: Julian, Colleen Glyde
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.