Adaptive resistance to AR inhibitors in low-oxygen environments linked to GPT1 metabolism
Official title: Adaptive resistance to AR inhibitors in hypoxia by GPT1
Funded at Oregon Health & Science University · NIH-11325371 · Data updated 2026-11-12
This grant looks at why prostate cancer becomes resistant to AR-targeting therapies when oxygen is scarce, by studying the GPT1 enzyme.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 18, 2023 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $311,208 |
| NIH project number | 5R01CA279964-04 |
| Project ID | NIH-11325371 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with AR+ metastatic prostate cancer who may experience resistance to AR inhibitors could be relevant for future trials or translational research.
✕Less likely to help
Early-stage disease or non-AR-driven prostate cancer may not benefit directly from this research.
What this research studies
If successful, findings could explain how low oxygen helps prostate cancer evade standard AR-targeted treatments and may point to new strategies to overcome this resistance. Researchers will examine metabolic changes around GPT1 and how these changes support cancer cell survival under therapy. The study uses human cancer biology concepts but aims to translate the knowledge toward better treatment options for patients with AR+ metastatic prostate cancer.
Why it matters
Potential benefit: Could lead to new approaches to prevent or overcome resistance to AR-targeted therapies in prostate cancer.
How similar studies have gone: Prior work has linked hypoxia and metabolic changes to drug resistance in cancer, with growing evidence but ongoing need for concrete targets like GPT1.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Qian, Zheng David — Oregon Health & Science University
- Study coordinator: Qian, Zheng David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.