Condition
HIV Pre-exposure Prophylaxis clinical trials and research
As of November 12, 2026, Find a Trial lists 6 HIV Pre-exposure Prophylaxis clinical trials that are recruiting, at sites in 5 countries (most in United States (3), Kenya (2), South Africa (1)). By phase: Phase 3 (1), Phase 4 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 5Countries
Newest HIV Pre-exposure Prophylaxis clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Pharmacist-guided PEP/PrEP Access Using PEPPI Software | — | Del Mar, California | Recruiting | Jul 6, 2026 |
| PrEP Linkage With Immediate Medications in the Emergency Department | — | Dallas, Texas | Recruiting | Mar 10, 2026 |
| Boosting long-acting injectable PrEP use among Latine gay/bisexual men and transgender women in the South | Phase 4 | Durham, North Carolina | Recruiting | Oct 20, 2025 |
| PrEP delivery led by HIV testing counselors in Kenyan clinics | — | Kisumu | Recruiting | Jul 29, 2025 |
| Monthly MK-8527 to prevent HIV-1 infection | Phase 3 | Homabay County, Homa Bay County and 29 other locations | Recruiting | Jul 17, 2025 |
| Observing HIV infection risks among high-risk individuals in Vienna | — | Vienna | Recruiting | Apr 13, 2022 |
All recruiting trials (6)
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Pharmacist-guided PEP/PrEP Access Using PEPPI Software
This trial tests whether the PEPPI software helps pharmacists provide PEP/PrEP and helps patients access these HIV prevention options.
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PrEP Linkage With Immediate Medications in the Emergency Department
This study tests starting PrEP right in the Parkland Memorial Hospital ED and linking patients to ongoing PrEP care to see if it increases PrEP uptake in Dallas.
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Boosting long-acting injectable PrEP use among Latine gay/bisexual men and transgender women in the South
This project will try giving long-acting injectable PrEP (lenacapavir) through a community clinic to Latine gay and bisexual men and transgender women in Durham to see if people stay on PrEP longer.
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PrEP delivery led by HIV testing counselors in Kenyan clinics
A counselor-led approach is being tested to see if it helps deliver PrEP in public health clinics for people in Kenya who may be at risk for HIV.
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Monthly MK-8527 to prevent HIV-1 infection
This study will test whether taking MK-8527 once a month prevents HIV-1 better than daily oral PrEP in HIV-negative, sexually active cisgender women.
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Observing HIV infection risks among high-risk individuals in Vienna
This study looks at the risk factors for new HIV infections among HIV-negative men who have sex with men and transgender individuals in Vienna to better understand how the virus spreads in these groups.
Related topics
Quick answers
How many HIV Pre-exposure Prophylaxis clinical trials are recruiting right now?
6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 5 countries. The most sites are in United States (3 trials), Kenya (2 trials), South Africa (1 trial), Uganda (1 trial), Austria (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.